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Filtering by: Creator Eby, Sean D. Remove constraint Creator: Eby, Sean D. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

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  • Innovative Bioanalytical Tools & Methods for Combinatorial Non-Coding RNA Analysis

    Creator:
    Zhang, Lulu
    Abstract:
    Recently researchers have discovered that groups of small non-coding RNAs (ncRNAs) play regulatory roles in gene expression and participate in various biological processes. For example, pathogenesis of many diseases, cell cycle regulation, and signaling pathways. Intracellular and live cell imaging of small ncRNA groups will reveal their relative expression levels...
    Resource Type:
    Dissertation
    Full Text:
    Sean M. Burrows Recently researchers have discovered that groups of small non-coding RNAs

  • Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

    Creator:
    Larkey, Nicholas E.
    Abstract:
    One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
    Resource Type:
    Dissertation
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    Abstract approved: ______________________________________________________ Sean M. Burrows

  • Gold Nanostars: Spectroscopic and Physical Properties

    Creator:
    Zhou, Lixia
    Abstract:
    Tethering fluorophores on metal nanoparticles for metal enhanced fluorescence (MEF) has attracted a lot of attention from scientists interested in fluorescence based approaches. MEF has many benefits in fluorescence related techniques, because the analytical signal increases and enables potentially lower detection limits or better sensitivity. Many types of nanoparticles have...
    Resource Type:
    Dissertation
    Full Text:
    Sean M. Burrows Tethering fluorophores on metal nanoparticles for metal enhanced

  • CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

    Creator:
    Almlie, C. Kyle
    Abstract:
    Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
    Resource Type:
    Dissertation
    Full Text:
    approved: ______________________________________________________ Sean M. Burrows Fluorescence has

  • Revealing Ultrafast Dynamics and Functional Basis of Potential Biomedical Tools from Calcium Sensing to Optogenetics

    Creator:
    Tachibana, Sean R.
    Abstract:
    Photoactivated biomedical tools like fluorescent biosensors and optogenetic proteins have increased in popularity due to the precision targeting and activation used for in vivo applications. In nature, the initially discovered parent proteins exhibit properties such as fluorescence quantum yield (FQY), fluorescence color, and photoswitching dynamics that are unfavorable in mammalian...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Sean R

  • Capturing Molecular Movies of Organic and Organometallic Systems in Solution by Ultrafast Spectroscopy

    Creator:
    Boulanger, Sean A.
    Abstract:
    Ultrafast spectroscopy can exploit the structure-function relationship of chemical- and biological-based systems. More specifically, femtosecond stimulated Raman spectroscopy (FSRS) provides ground- and excited-state vibrational information with simultaneously high spectral (spatial) and temporal resolutions. The electronic counterpart, femtosecond transient absorption (fs-TA), complements FSRS data analysis as part of a comprehensive approach...
    Resource Type:
    Dissertation
    Full Text:
    THE DISSERTATION OF Sean Boulanger for the degree of Doctor of Philosophy in Chemistry presented

  • Structure-property relationships of layered oxypnictides

    Creator:
    Muir, Sean W.
    Abstract:
    Investigating the structure-property relationships of solid state materials can help improve many of the materials we use each day in life. It can also lead to the discovery of materials with interesting and unforeseen properties. In this work the structure property relationships of newly discovered layered oxypnictide phases are presented...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Sean W. Muir for the

  • Novel Charge Carriers for Aqueous Electrochemical Energy Storage

    Creator:
    Sandstrom, Sean K.
    Abstract:
    The continued long-term use of fossil fuels as a primary energy source has resulted in dramatic increases in greenhouse gas emissions and the associated concerns of climate change and environmental pollution. A key strategy to circumvent these issues is a global shift away from fossil fuels toward renewable energy sources....
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Sean Kieran

  • Functionalization of carbon nanotubes for effective biosensing and potential biomedical applications

    Creator:
    Adenuga, Adeniyi A.
    Abstract:
    Since their discovery in the 1990s, the great potential of carbon nanotubes (CNTs) has made them a focus of many research endeavors, including their application as components of biosensors. The inherent chemical "inertness" of CNTs makes their application to biosensing a challenge. It is necessary to "decorate" their surfaces to...
    Resource Type:
    Dissertation
    Full Text:
    Dr. Sean Burrows for his willingness to participate in my defense committee at the last moment

  • Semiconductor Nanocrystals as Detection Components in Microfluidic Analytical Systems

    Creator:
    Pengpumkiat, Sumate
    Abstract:
    Miniaturized and portable microfluidic analytical platforms have been widely explored in the broad field of chemical analysis. The concept of microfluidics offer a number of important advantages, including low reagent consumption, low-cost detection, high sample throughput, and shorter analysis time. Semiconductor nanocrystals or quantum dots have been extensively utilized in...
    Resource Type:
    Dissertation
    Full Text:
    my appreciation to my graduate committees: Dr. Staci Simonich, Dr. Sean Burrows, Dr. Dipankar Koley