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Filtering by: Creator Hoyer, J. Steen Remove constraint Creator: Hoyer, J. Steen Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

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  • Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

    Creator:
    Adpressa, Donovon A.
    Abstract:
    Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
    Resource Type:
    Dissertation
    Full Text:
    bioassay testing of secondary metabolites described in Chapter Three. Prof. Philip J. Proteau assisted

  • Fluorescence studies on the bases of the nucleic acids in solution at room temperature

    Creator:
    Hauswirth, William Walter
    Abstract:
    Fluorescence of adenine, guanine, thymine, cytosine, and uracil has been detected at room temperature in neutral aqueous solution using a digital signal accumulation technique and right angle fluorescence detection from solutions with absorbances between 0. 4 and 0. 7. The quantum yields are respectively 2.6 x 10⁻⁴, 3.0 x 10⁻⁴,...
    Resource Type:
    Dissertation
    Full Text:
    electrons j in the molecule, er.J . J A more explicit view of electronic states in organic molecules

  • Polymeric submicron optical ion-selective sensors

    Creator:
    Bychkova, Valeriya
    Abstract:
    Ion-selective polymeric optical sensors – ion optodes – are a promising alternative to ion-selective electrodes and fluorescent dyes for analytical and biological applications, e.g. extra- and intracellular measurements. They are non-toxic, highly selective robust probes for ionic fluxes monitoring. A large-scale fabrication of ion optodes using a solvent displacement method...
    Resource Type:
    Dissertation
    Full Text:
    , 258, 778-781. (5) Ross, W. N. Biophys. J. 1993, 64, 1655-1656. (6) Buck, S., Xu, H., Brasuel, M

  • The extraction of menthol from peppermint oil (Mentha piperita Linne)

    Creator:
    Isensee, Robert William
    Resource Type:
    Masters Thesis
    Full Text:
    - rate ester and. then steen distilled the menthol over. similiar approach is partially d.esoribed (10

  • A study of the diffusion velocity of ovalbumin

    Creator:
    Ray, Billy Roger
    Resource Type:
    Masters Thesis
    Full Text:
    Investi1ation 54 Tr1) -Tt'vDr'i J. u.w It is recognized. that know1ede of the properties of such

  • Proteomic approach to the analysis of DNA-binding proteins using mass spectrometry

    Creator:
    Stapels, Martha Degen
    Abstract:
    In proteomic studies, separate experimental protocols have been necessary to identify proteins, determine their function, and predict their three-dimensional structure. In this study, a function-based separation of proteins was conceived to fractionate proteins prior to enzymatic digestion. In the initial demonstration of this technique, a DNA substrate was used to...
    Resource Type:
    Dissertation
    Full Text:
    ., Auberry, D.L., Battista, J.R., Daly, M.J., Fredrickson, J., Hixson, K.K., Kostandarithes, H., Masselon, C

  • Electrochemistry at a reticulated vitreous carbon flow electrode

    Creator:
    Fahey, Jefferson Vincent
    Abstract:
    The electrochemistry of cadmium at a Reticulated Vitreous Carbon (RVC) electrode has been studied to determine the suitability of RVC as a working electrode for the electrochemical preconcentration of cadmium in the corrosive environment of zirconium dissolved in hydrofluoric acid. The electrochemistry in this investigation deals with deposition of solid...
    Resource Type:
    Masters Thesis
    Full Text:
    for commiseration, and he had some excellent abrasive papers too! The understanding and support of J

  • Gas-phase fragmentation chemistry of protonated peptide ions

    Creator:
    Bythell, Benjamin James
    Abstract:
    The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
    Resource Type:
    Dissertation
    Full Text:
    paper J. Am. Soc. Mass Spectrom., 2007, 7, 1291-1303 (Chapter 2). Prof. Chrys Wesdemiotis was a minor

  • New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

    Creator:
    Overacker, Ross D.
    Abstract:
    Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
    Resource Type:
    Dissertation
    Full Text:
    described antimycin A8a (3.1).33 J values are shown in parenthesis (Hz

  • Tracking Photoinduced Primary Events with Femtosecond Stimulated Raman Spectroscopy and Calculations

    Creator:
    Wang, Yanli
    Abstract:
    Femtosecond stimulated Raman spectroscopy (FSRS) is a powerful ultrafast technique which can track photoinduced excited state structural events on femtosecond (fs) to picosecond (ps) timescales. In addition to high temporal and spectral resolutions, FSRS provides a broad spectral window from ca. 100—2000 cm-1 for detection, enabling the direct mapping of...
    Resource Type:
    Dissertation