Index Catalog // ScholarsArchive@OSU

Total synthesis of phorboxazole A

Creator:: Lee, Tae Hee
Abstract:: The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
Resource Type:: Dissertation
Full Text:: , Professor Dr. Rich G. Carter, Dr. Miroslav Terinek, Dr. David Ihle, Helmars Smits, Keith Schwartz, David

Studies towards the total synthesis of (-)-kendomycin

Creator:: Smits, Helmars
Abstract:: Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
Resource Type:: Dissertation
Full Text:: committee members, Professor David Horne, Professor Paul Blakemore, Professor Max Deinzer and Professor

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:: Tonsiengsom, Sorasaree
Abstract:: Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Resource Type:: Dissertation
Full Text:: : STUDIES TOWARD THE TOTAL SYNTHESIS OF ALKALOIDS: NAGELAMIDE A AND D, AGELASTATIN D, DRAGMACIDIN A-C

Semi-volatile fluorinated organic compounds in Asian and Pacific Northwestern U.S. air masses

Creator:: Piekarz, Arkadiusz M.
Abstract:: Current studies suggest that perfluorinated organic compounds, such as fluorotelomer alcohols (FtOHs) in the troposphere, may be precursors of perfluorocarboxylic acids and perfluorosulfonates in remote regions. Fluorinated organic compounds were investigated in archived extracts collected from remote locations in Okinawa, Japan (HSO) and Mount Bachelor, Oregon (MBO) during the springs...
Resource Type:: Masters Thesis
Full Text:: Fluorochemicals are stable (C-F bond energy ~110 kcal/mol) and chemically inert. They can repel both water and

Analysis of semi-volatile organic contaminants and their accumulation in remote aquatic ecosystems of the western US

Creator:: Ackerman, Luke K.
Abstract:: Many pesticides, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons are persistent, bio-accumulative, and toxic. These semi-volatile organic compounds (SOCs) can undergo atmospheric transport and deposition in cold, remote ecosystems. A better understanding of their accumulation in the fish of these ecosystems is important to better predict...
Resource Type:: Dissertation
Full Text:: , analysis, and discussions; David Schmedding and Glenn Wilson for their patience, invaluable assistance

Development, validation and the application of a congener specific photodegradation model for PBDEs

Creator:: Zeng, Xia
Abstract:: The thermodynamic properties of 39 PBDEs have been calculated using Gaussian 03 on the B3LYP/6-31G(d)//B3LYP/6-31G(d) level. The PBDE congeners' enthalpies of formation increase with increasing number of bromines and show a strong dependence on the bromine substitution pattern. The effects of bromine substitution pattern have been quantitatively studied by GAM...
Resource Type:: Dissertation
Full Text:: constants for the three different degradation processes are controlled by C-Br bond dissociation energy

From electrophoresis to dielectrophoresis: designing, fabricating, and evaluating an electroformed ratchet type microfluidic dielectrophoresis device

Creator:: Gonzalez, Carlos F.
Abstract:: Dielectrophoresis (DEP) is a separation method in which a non-uniform electric field is used to induce a dipole moment in a suspended particle. If the polarization of the particle is greater than that of the suspending medium, the particle will move towards the region of higher field strength (positive DEP);...
Resource Type:: Dissertation
Full Text:: . (-) (+) -+ --- -- - - + + + + + + + (+) (-)- +--- ---- + + + + + + + 28 (c) (a) +DEP-DEP Offset electrodes Non-offset electrodes (b) Electrode Electrode

Trans-Pacific and regional atmospheric transport of anthropogenic semivolatile organic compounds in the western U.S.

Creator:: Primbs, Toby
Abstract:: The atmospheric transport of anthropogenic semivolatile organic compounds (SOCs) from Asian sources to the Western U.S. was investigated. In addition, the SOC extraction method was optimized. Hansen solubility parameter plots were used to aid in the pressurized liquid extraction (PLE) solvent selection of air sampling media in order to minimize...
Resource Type:: Dissertation
Full Text:: , black carbon, and submicron aerosol analysis Chapter 3. David Schmedding assisted in the sampler

Studying fusion reactions for effect of PCN on heavy nucleus formation and for nuclear structure effects

Creator:: Naik, Radhika
Abstract:: The fusion reaction ²⁰⁸Pb (⁵⁰Ti, xn) ²⁵⁸⁻x Rf (x = 1-3) was studied to determine PCN (probability that the mononucleus system evolves to form a compound nucleus inside the fission saddle point) and to establish the value of Wsur (survival probability) for the given reaction experimentally. The fission excitation function...
Resource Type:: Dissertation
Full Text:: . This work was funded in part by The OSU Chemistry Department, the David P. Shoemaker Memorial

Nonmuscle myosins II-B and Va are components of detergentresistant membrane skeletons derived from mouse forebrain

Creator:: Ishmael, Jane E., Safic, Masa, Amparan, David, Vogel, Walter K., Pham, Tuyen, Marley, Kevin, Filtz, Theresa M., and Maier, Claudia S.
Abstract:: Myosins are actin-based molecular motors that may have specialized trafficking and contractile functions in cytoskeletal compartments that lack microtubules. The postsynaptic excitatory synapse is one such specialization, yet little is known about the spatial organization of myosin motor proteins in the mature brain. We used a proteomics approach to determine...
Resource Type:: Preprint and Article
Full Text:: 1, David Amparan 1, Walter K. Vogel 1, Tuyen Pham1, Kevin Marley2, Theresa M. Filtz1 and Claudia S

ScholarsArchive@OSU

Total synthesis of phorboxazole A

Studies towards the total synthesis of (-)-kendomycin

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Semi-volatile fluorinated organic compounds in Asian and Pacific Northwestern U.S. air masses

Analysis of semi-volatile organic contaminants and their accumulation in remote aquatic ecosystems of the western US

Development, validation and the application of a congener specific photodegradation model for PBDEs

From electrophoresis to dielectrophoresis: designing, fabricating, and evaluating an electroformed ratchet type microfluidic dielectrophoresis device

Trans-Pacific and regional atmospheric transport of anthropogenic semivolatile organic compounds in the western U.S.

Studying fusion reactions for effect of PCN on heavy nucleus formation and for nuclear structure effects

Nonmuscle myosins II-B and Va are components of detergentresistant membrane skeletons derived from mouse forebrain

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