Index Catalog // ScholarsArchive@OSU

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Creator:: Emerson, Christopher R.
Abstract:: Sulfoxide-ligand exchange (SLE) and asymmetric halogen-metal exchange (AHME) processes were separately examined for the enantioselective synthesis of functionalized alpha-haloalkylmetal (carbenoid) reagents. Carbenoids derived from SLE were used to effect stereospecific reagent-controlled homologation (StReCH) of boronic esters and those generated via AHME were engaged in Darzens-type chemistry with aldehydes. Abstract for...
Resource Type:: Dissertation

Nutritional muscular dystrophy production and pectoral muscle 5'-nucleotidase activity in the chick

Creator:: Roffler, Sheila Ann
Abstract:: In an attempt to find a laboratory species which develops an experimental myopathy similar to white muscle disease (WMD) in lambs, comparative studies of nutritional muscular dystrophy of chicks were initiated. This condition was grossly visible as white striations running parallel with the fibers of the pectoral muscles and was...
Resource Type:: Masters Thesis
Full Text:: major professor, Dr. Paul H. Weswig, during these studies. Special thanks are also due Dr. John R

Computational Rationalizations of Mechanism and Stereocontrol in Small-Molecule Lewis Base Organocatalysis

Creator:: McCauley-Walden, Daniel W.
Abstract:: My work has focused on investigating synthetic organic reactions using applied computational methods. Non-covalent interactions are critical to catalysis, mechanism, and stereoselectivity, with the most prominent interaction for isothioureas being the S···O contact between the catalyst sulfur atom and the oxygen of the acyl group. A comprehensive joint experimental and...
Resource Type:: Dissertation
Full Text:: Stereocontrol in Small-Molecule Lewis Base Organocatalysis. Abstract approved: Paul Ha-Yeon

Rationalization and innovative design of asymmetric organocatalysts through computational investigation

Creator:: Johnston, Ryne Connell
Abstract:: My work on computing complex catalyzed organic transformations reveals that only a few subtle chemical factors, e.g. non-classical hydrogen bonding, (hyper)conjugation and steric effects, common across different catalyst manifolds are critical for catalysis and selectivity. Rational manipulation and exploitation of these factors has led to improved catalyst designs, which has...
Resource Type:: Dissertation
Full Text:: Organocatalysts through Computational Investigation. Abstract approved: Paul Ha-Yeon Cheong

Insights and Patterns from Quantitative and Statistical Analyses of Chemical Systems

Creator:: Grove, Markas Albert
Abstract:: The work presented here is the culmination of efforts in describing complex chemical systems with statistical methods, thereby providing relatively simple quantitative models and easily comprehensible qualitative insights. The following investigations have various goals, such as development of new methods, fundamental understanding, molecular control of chemical species, and advancement of...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Paul Ha-Yeon Cheong

Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

Creator:: Barsamian, Adam L.
Abstract:: Two distinct strategies were explored for the enantioselective synthesis of α-heteroatom substituted alkyl boronic esters by stereoselective reagent-controlled homologation using transient chiral carbenoid reagents CHYMX (Y = heteroatom, X = nucleofuge, M = electrofuge). In the first case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates using α-metalated S,O- and...
Resource Type:: Dissertation
Full Text:: . Paul R. Blakemore Two distinct strategies were explored for the enantioselective synthesis of α

Strategic Application of Computations to Diverse Chemical Systems

Creator:: Brueckner, Alexander C.
Abstract:: My work has focused on streamlining the study of organic compound structure, properties, and reactions by 1) understanding and using available computational software, 2) developing software packages to facilitate data manipulation as well as augment public programs, and 3) applying public and in-house developed software to further the understanding of...
Resource Type:: Dissertation
Full Text:: . Abstract approved: ______________________________________________________ Paul Ha-Yeon Cheong My

Electric moment studies of a series of related hydrazine derivates

Creator:: Frey, Paul Reheard
Resource Type:: Dissertation
Full Text:: STUDIES OF A SERIES OF RELATED HDRAZINE DERIVATIVES by PAUL REdEARD FREY A ÍEiESIS submitted

Part I: Synthetic studies toward the southern portion of Azaspiracid-1; Part II: Total synthesis of amphidinolide B₁ and the proposed structure of amphidinolide B₂

Creator:: Lu, Liang
Abstract:: The structural architecture present in marine toxin azaspiracid - 20 stereocenters, 9 rings, 3 separated spirocenters - has attracted considerable synthetic attention. Our efforts toward the synthesis of azaspiracid have led to the completion of both C₁-C₂₆ northern and C₂₇-C₄₀ southern halves. Herein, the synthesis of southern FGHI ring system...
Resource Type:: Dissertation
Full Text:: extend my appreciation to my committee members, Prof. Paul R. Blakemore, Prof. Kevin P. Gable, Prof

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Creator:: Overacker, Ross D.
Abstract:: Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Resource Type:: Dissertation
Full Text:: positivity, hard work, and determination are a model for all. I would like to thank Paul Blakemore for

ScholarsArchive@OSU

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Nutritional muscular dystrophy production and pectoral muscle 5'-nucleotidase activity in the chick

Computational Rationalizations of Mechanism and Stereocontrol in Small-Molecule Lewis Base Organocatalysis

Rationalization and innovative design of asymmetric organocatalysts through computational investigation

Insights and Patterns from Quantitative and Statistical Analyses of Chemical Systems

Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

Strategic Application of Computations to Diverse Chemical Systems

Electric moment studies of a series of related hydrazine derivates

Part I: Synthetic studies toward the southern portion of Azaspiracid-1; Part II: Total synthesis of amphidinolide B₁ and the proposed structure of amphidinolide B₂

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

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