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Filtering by: Creator Martin, Mark A. Remove constraint Creator: Martin, Mark A. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

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  • Total synthesis of phorboxazole A

    Creator:
    Lee, Tae Hee
    Abstract:
    The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
    Resource Type:
    Dissertation
    Full Text:
    SYNTHESIS OF C1-C32 MACROLACTONE OF PHORBOXAZOLE A AN

  • Studies toward the synthesis of halichlorine and pinnaic acid

    Creator:
    Korf, Eric A.
    Abstract:
    Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF Eric A. Korf for the degree of Doctor of Philosophy in Chemistry presented on July 24

  • Studies towards the total synthesis of (-)-kendomycin

    Creator:
    Smits, Helmars
    Abstract:
    Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
    Resource Type:
    Dissertation
    Full Text:
    .; Umbreit, M.A.; Nieh, M.T.; Flood, T.C. J. Am. Chem. Soc. 1972, 94, 6538. 17. a) Martin, H.J

  • Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

    Creator:
    Tonsiengsom, Sorasaree
    Abstract:
    Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
    Resource Type:
    Dissertation
    Full Text:
    : STUDIES TOWARD THE TOTAL SYNTHESIS OF ALKALOIDS: NAGELAMIDE A AND D, AGELASTATIN D, DRAGMACIDIN A-C

  • Semi-volatile fluorinated organic compounds in Asian and Pacific Northwestern U.S. air masses

    Creator:
    Piekarz, Arkadiusz M.
    Abstract:
    Current studies suggest that perfluorinated organic compounds, such as fluorotelomer alcohols (FtOHs) in the troposphere, may be precursors of perfluorocarboxylic acids and perfluorosulfonates in remote regions. Fluorinated organic compounds were investigated in archived extracts collected from remote locations in Okinawa, Japan (HSO) and Mount Bachelor, Oregon (MBO) during the springs...
    Resource Type:
    Masters Thesis
    Full Text:
    , such a fluorotelomer alcohols (FtOHs) in the troposphere, may be precursors of perfluorocarboxylic

  • Analysis of semi-volatile organic contaminants and their accumulation in remote aquatic ecosystems of the western US

    Creator:
    Ackerman, Luke K.
    Abstract:
    Many pesticides, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons are persistent, bio-accumulative, and toxic. These semi-volatile organic compounds (SOCs) can undergo atmospheric transport and deposition in cold, remote ecosystems. A better understanding of their accumulation in the fish of these ecosystems is important to better predict...
    Resource Type:
    Dissertation
    Full Text:
    in cold, remote ecosystems. A better understanding of their accumulation in the fish of these

  • Determination of fluorochemicals in waste-dominated aqueous systems

    Creator:
    Huset, Carin A.
    Abstract:
    While fluorochemicals have been detected all over the world and in wastewater treatment plants, the effect of wastewater effluent on the receiving waters has not been evaluated. In the first study, the mass flow of fluorochemicals emanating from wastewater treatment plants along the Glatt River in Switzerland was evaluated. The...
    Resource Type:
    Dissertation
    Full Text:
    Biochemistry 1981, 118, 336-343. (19) Martin, J. W.; Mabury, S. A.; O'Brien, P. J. Chemico-Biological

  • Trans-Pacific and regional atmospheric transport of anthropogenic semivolatile organic compounds in the western U.S.

    Creator:
    Primbs, Toby
    Abstract:
    The atmospheric transport of anthropogenic semivolatile organic compounds (SOCs) from Asian sources to the Western U.S. was investigated. In addition, the SOC extraction method was optimized. Hansen solubility parameter plots were used to aid in the pressurized liquid extraction (PLE) solvent selection of air sampling media in order to minimize...
    Resource Type:
    Dissertation
    Full Text:
    from China. A large proportion of the variation in the current use pesticides, gas-phase PAHs, and

  • Graphite intercalation compounds containing fluoroanions

    Creator:
    Katinonkul, Watcharee
    Abstract:
    New chemical synthesis strategies have been investigated for the preparation of acceptor-type graphite intercalation compounds (GIC's) with fluoroanions in order to obtain new materials and to develop a better understanding of the synthetic approaches and properties of the products. New GIC's containing borate chelate anion such as bis(oxalato)borate, CxB[OC(O)C(O)O]₂•δF, are...
    Resource Type:
    Dissertation
    Full Text:
    to obtain new materials and to develop a better understanding of the synthetic approaches and

  • Studying fusion reactions for effect of PCN on heavy nucleus formation and for nuclear structure effects

    Creator:
    Naik, Radhika
    Abstract:
    The fusion reaction ²⁰⁸Pb (⁵⁰Ti, xn) ²⁵⁸⁻x Rf (x = 1-3) was studied to determine PCN (probability that the mononucleus system evolves to form a compound nucleus inside the fission saddle point) and to establish the value of Wsur (survival probability) for the given reaction experimentally. The fission excitation function...
    Resource Type:
    Dissertation
    Full Text:
    PCN (probability that the mononucleus system evolves to form a compound nucleus inside the fission