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Filtering by: Creator Nielsen, James F. Remove constraint Creator: Nielsen, James F. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

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  • Total synthesis of phorboxazole A

    Creator:
    Lee, Tae Hee
    Abstract:
    The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
    Resource Type:
    Dissertation
    Full Text:
    : James D. White The total synthesis of a highly potent cytotoxic marine natural product

  • Studies toward the synthesis of halichlorine and pinnaic acid

    Creator:
    Korf, Eric A.
    Abstract:
    Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
    Resource Type:
    Dissertation
    Full Text:
    approved: James D. White Three approaches toward the core of halichlorine and

  • Studies towards the total synthesis of (-)-kendomycin

    Creator:
    Smits, Helmars
    Abstract:
    Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
    Resource Type:
    Dissertation
    Full Text:
    :_____________________________________________________ James D. White Studies towards the total synthesis of (−)-kendomycin (1), a bacterial

  • Polarization spectroscopy and photodissociation studies of nitroaromatic compounds in the gas phase

    Creator:
    Abbott, James E.
    Abstract:
    The central purpose of this dissertation was to explore and expand the use of an uniform electric field for orientation and for subsequent spectroscopic investigation of asymmetric polar molecules in the gas phase. The systems of study were nitrobenzene (NB) and the nitrotoluene (NT) isomers. We were able to quantitatively...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF James E. Abbott, Jr. for the degree of Doctor of Philosophy in Chemistry presented on

  • Semi-volatile fluorinated organic compounds in Asian and Pacific Northwestern U.S. air masses

    Creator:
    Piekarz, Arkadiusz M.
    Abstract:
    Current studies suggest that perfluorinated organic compounds, such as fluorotelomer alcohols (FtOHs) in the troposphere, may be precursors of perfluorocarboxylic acids and perfluorosulfonates in remote regions. Fluorinated organic compounds were investigated in archived extracts collected from remote locations in Okinawa, Japan (HSO) and Mount Bachelor, Oregon (MBO) during the springs...
    Resource Type:
    Masters Thesis
    Full Text:
    , Jennifer A. Field, and Douglas F. Barofsky. 7 and TABLE OF CONTENTS Pa

  • Determination of fluorochemicals in waste-dominated aqueous systems

    Creator:
    Huset, Carin A.
    Abstract:
    While fluorochemicals have been detected all over the world and in wastewater treatment plants, the effect of wastewater effluent on the receiving waters has not been evaluated. In the first study, the mass flow of fluorochemicals emanating from wastewater treatment plants along the Glatt River in Switzerland was evaluated. The...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: _____________________________________________________ Douglas F. Barofsky

  • From electrophoresis to dielectrophoresis: designing, fabricating, and evaluating an electroformed ratchet type microfluidic dielectrophoresis device

    Creator:
    Gonzalez, Carlos F.
    Abstract:
    Dielectrophoresis (DEP) is a separation method in which a non-uniform electric field is used to induce a dipole moment in a suspended particle. If the polarization of the particle is greater than that of the suspending medium, the particle will move towards the region of higher field strength (positive DEP);...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF Carlos F. Gonzalez for the degree of Doctor of Philosophy in Chemistry presented on

  • Trans-Pacific and regional atmospheric transport of anthropogenic semivolatile organic compounds in the western U.S.

    Creator:
    Primbs, Toby
    Abstract:
    The atmospheric transport of anthropogenic semivolatile organic compounds (SOCs) from Asian sources to the Western U.S. was investigated. In addition, the SOC extraction method was optimized. Hansen solubility parameter plots were used to aid in the pressurized liquid extraction (PLE) solvent selection of air sampling media in order to minimize...
    Resource Type:
    Dissertation
    Full Text:
    ) Hung, H.; Blanchard, P.; Halsall, C. J.; Bidleman, T. F.; Stern, G. A.; Fellin, P.; Muir, D. C. G

  • The chemical nature of the extractives from the bark of red alder, alnus rubra, Bong

    Creator:
    Becker, Edward Samuel
    Abstract:
    The purpose of this investigation was to determine the nature of the extractives from red alder bark in an effort to discover the materials which cause the red stain in red alder wood. Samples of bark and wood were obtained and successively extracted with hexane, benzene, ether, ethanol, and hot...
    Resource Type:
    Masters Thesis
    Full Text:
    to thank Dr. E. F. Kurth for his suggestions which aided in this investigation, and to the Orville

  • Development of fragmentation techniques in mass spectrometry for biological applications

    Creator:
    Ji, Hong
    Abstract:
    In this dissertation, I present the work of developing more efficient and economical techniques for fragmenting large bio-molecules, and ultimately making mass spectrometry a more powerful tool in proteomics, DNA sequencing, and other areas of biomolecular analysis. Aiming at lowering the installation and operating cost, and delivering electron capture dissociation...
    Resource Type:
    Dissertation
    Full Text:
    ) trans- (b) vaccenic acid , (e) erucic acid, and (f) brassidic acid……………....…..…. 121 LIST OF