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Filtering by: Committee Member Peachey, Ronald E. Remove constraint Committee Member: Peachey, Ronald E. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

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  • Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

    Creator:
    Wang, Jing
    Abstract:
    Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
    Resource Type:
    Dissertation
    Full Text:
    antioxidants, including ubiquinone, ascorbate (vitamin C), lipid soluble -tocopherol (vitamin E), and

  • Studies towards the total synthesis of (-)-kendomycin

    Creator:
    Smits, Helmars
    Abstract:
    Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
    Resource Type:
    Dissertation
    Full Text:
    kendomycin. Several methods for isomerizing Z olefin 30 to an E olefin were explored, but the only