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Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Creator:: Li, Xin
Abstract:: This dissertation is separated into two parts according to the two major distinct research projects. In Part I, the full account of synthetic studies toward C10-functionalized lycopodium alkaloids is described. In Part II, the detailed discussion on the exploration of the Pummerer cyclization methodology and its application to the total...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Rich G. Carter This dissertation is separated into two parts according to the two major

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation
Full Text:: Amphidinolide C; Part II: Computational Study on Proline Sulfonamide- catalyzed Aldol Reaction

Chiral synthesis of monic acid C

Creator:: Theramongkol, Parinya
Abstract:: Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...
Resource Type:: Dissertation
Full Text:: d,e,f,g Se Ph Bn0 0 --OBn 18 b,c i,j,k 21 ( R = SiPh2t-Bu ) 19 15 10 Reagents: a) PhSeCl

Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: .; Gunnarsson, I.; Bishop, W. R.; Kreutner, W.; Horan, A. C.; Patel, M. G.; Gullo, V. P.; Puar, M. S. J

Vibrational and reorientational lifetimes in liquids determined by Raman spectroscopy

Creator:: Morgan, Larry G.
Abstract:: Studies of anisotropic and isotropic Raman line shape yield information about the rotational motion (rotational correlation function) and non-reorientational (vibrational) lifetimes. The rotational motion of carbon disulfide has been studied previously by the techniques of Raman spectroscopy (6, 43), Rayleigh scattering (43, 46) and direct measurement (47). This work was...
Resource Type:: Dissertation
Full Text:: ) 64Tr4 v n4 N" I (obs I-) I ( (a )2+ (3-1-4 gn 0 \ WM' 45 Z )c mum? J. i (obs. ) = 64.74v4 Nn I 4 g 0

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Creator:: Shaw, Subrata
Abstract:: This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Resource Type:: Dissertation
Full Text:: References 1. Livesey, G.; Brown, J. C. J. Nutr. 1995, 125, 3020. 2. Raymer, G. S.; Hartman, D. E.; Rowe, W

Thermodynamics of hydrazine in aqueous solution at 25⁰ C

Creator:: Bushnell, Vernon Clifford
Resource Type:: Masters Thesis
Full Text:: specific heats at 2c and 25°C. of the mono and. dichiorides and. bromides, and of theperchiorate. They

Mechanistic studies on Re(V) mediated C-O bond transformations

Creator:: Zhuravlev, Fedor
Abstract:: In situ, reduction of Cp*ReO₃ by PPh₃ to form (Cp*ReO)₂(μ-O)₂ allows catalytic deoxygenation of epoxides, however, conproportionation between Reⱽ and Reⱽᴵᴵ species to form clusters of ((Cp*Re)₃(μ-O)₆}²⁺(ReO₄⁻)2 and new compound {(Cp*Re)₃(μ²-O)₃(μ³-O⁾³ReO₃}⁺(ReO₄⁻) leads to removal of rhenium from the catalytic cycle and loss of activity, The epoxide deoxygenation mediated by (Cp*ReO)₂(μ-O)₂...
Resource Type:: Dissertation
Full Text:: -1 12°C); the following cycloreversion leads to a formation of Cp*Re03 and alkene, Primary 1 3c and

The relationship between pantothenic acid and vitamin G

Creator:: Holaday, Duncan Asa
Resource Type:: Masters Thesis
Full Text:: ., Lyman, C. M., Goodyear, G. H., Truesdail J. H., and Holeday, D., J. Am. Chem. Soc., 55, 2912 f1933

A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

Creator:: Saha, Mrinmoy
Abstract:: Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
Resource Type:: Dissertation
Full Text:: NaBH4 provided (-)-cermizine C 1.15. Scheme 1.18: Snider’s Syntheses of (-)-Senepodine G

ScholarsArchive@OSU

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Chiral synthesis of monic acid C

Studies towards the total syntheses of (+)-phomactins A, D and G

Vibrational and reorientational lifetimes in liquids determined by Raman spectroscopy

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Thermodynamics of hydrazine in aqueous solution at 25⁰ C

Mechanistic studies on Re(V) mediated C-O bond transformations

The relationship between pantothenic acid and vitamin G

A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

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