Index Catalog // ScholarsArchive@OSU

Comprehensive Analysis of The Brain Metabolome Using Mass Spectrometry in Conjunction with Data Analysis Techniques

Creator:: Khorani, Mona
Abstract:: Metabolomics has recently gained momentum in biomolecule research and complements the genomics and proteomics research space. Metabolomics strives to detect, identify, and quantify all metabolites present in biological samples. In particular, biomolecular analysis using ultra-performance liquid chromatography combined with mass spectrometry (UPLC-MS) has become increasingly important for metabolomic analyses. Similarly,...
Resource Type:: Dissertation
Full Text:: . Furthermore, I am grateful to Jeffrey Morre and Dr. Liping Yang for their invaluable assistance with mass

Storage Battery Chemistries with Earth Abundant Charge Carriers

Creator:: Hong, Jessica Junghwa
Abstract:: The demand for the development of sustainable energy is an all time high as we burn through limited fossil fuel reserves and as environmental concerns rise every year. Renewable energy sources such as wind and solar power have limitations due to inconsistent power supply that cannot meet the regular needs...
Resource Type:: Dissertation
Full Text:: . c),d) Cyclic voltammetry profiles for c) 5m KI electrolyte and d) 15 m ZnCl2 electrolyte. e) GCD

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Creator:: Lande, Claire, Rao, Sujaya, Morre, Jeffrey T., Galindo, Gracie, Kirby, Julie, Reardon, Patrick N., Bobe, Gerd, and Stevens, Jan Frederik
Abstract:: Linden (Tilia spp.), a profusely flowering temperate tree that provides bees with vital pollen and nectar, has been associated with bumble bee (Bombus spp.) mortality in Europe and North America. Bee deaths have been attributed, with inadequate evidence, to toxicity from mannose in nectar or starvation due to low nectar...
Resource Type:: Article
Full Text:: mortality: Metabolomic analysis of nectar and bee muscle Claire Lande1☯, Sujaya RaoID 1☯¤*, Jeffrey T

Using Computational Methods to Elucidate Reaction Mechanisms for Copper Catalyzed Reactions

Creator:: Caspary, Katherine E.
Abstract:: In this report, two studies are presented that utilize computations to predict and elucidate the reaction mechanisms of two different copper catalyzed reactions. Each study provides insight into the various chemical transformations, as well as the how and why behind regioselectivity and isotopic selectivity. The importance of this research is...
Resource Type:: Masters Thesis
Full Text:: 0.0 C F Cu FX N N -1.3 0.2 1.3 1.4 Cu L L O CF2X O G (k c a l/m o l) Reaction

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Creator:: Neuhaus, George F.
Abstract:: The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Resource Type:: Dissertation
Full Text:: discovery. 12 1.6 References (1) Dewick, P. M., Medicinal Natural Products: A Biosynthetic

Per- and Polyfluoroalkyl Substances (PFASs): Consumer Products, Protocols, and Percutaneous Absorption

Creator:: Rewerts, Justin N.
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are a group of anthropogenic compounds gaining notoriety as contaminants of emerging concern. With the frequent detection of PFAS in the environment, drinking water, and consumer products, awareness and concern from the public regarding PFAS is increasing. The two most notorious PFAS are perfluorooctanoate (PFOA)...
Resource Type:: Dissertation
Full Text:: military. Environ. Sci. Technol. 2012, 46, (13), 7120- 7127. 5. Company, M., The Science of Organic

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Creator:: Zhu, Chenxi
Abstract:: Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
Resource Type:: Dissertation
Full Text:: Biosci (Elite Ed), 2012. 4: p. 240-53. 11. Chopra, I. and M. Roberts, Tetracycline antibiotics: mode of

Bioprospecting the Chemical Diversity of Plant-associated Fungi

Creator:: González-Montiel, Gisela Abigail
Abstract:: Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
Resource Type:: Masters Thesis
Full Text:: . Jeffrey Stone (OSU) supplied the fungus Zasmidium pseudotsugae and has provided the genome data in

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Creator:: Song, Zifeng
Abstract:: Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
Resource Type:: Dissertation
Full Text:: Yang and Jeffrey Morré for their helps with MS and LC instrumentations in past years. I am grateful

Computational Rationalizations of Mechanism and Stereocontrol in Small-Molecule Lewis Base Organocatalysis

Creator:: McCauley-Walden, Daniel W.
Abstract:: My work has focused on investigating synthetic organic reactions using applied computational methods. Non-covalent interactions are critical to catalysis, mechanism, and stereoselectivity, with the most prominent interaction for isothioureas being the S···O contact between the catalyst sulfur atom and the oxygen of the acyl group. A comprehensive joint experimental and...
Resource Type:: Dissertation
Full Text:: review of the manuscript. Chapter 4. Mark D. Greenhalgh, Samuel M. Smith, James, E. Taylor, Zamira

ScholarsArchive@OSU

Comprehensive Analysis of The Brain Metabolome Using Mass Spectrometry in Conjunction with Data Analysis Techniques

Storage Battery Chemistries with Earth Abundant Charge Carriers

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Using Computational Methods to Elucidate Reaction Mechanisms for Copper Catalyzed Reactions

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Per- and Polyfluoroalkyl Substances (PFASs): Consumer Products, Protocols, and Percutaneous Absorption

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Bioprospecting the Chemical Diversity of Plant-associated Fungi

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Computational Rationalizations of Mechanism and Stereocontrol in Small-Molecule Lewis Base Organocatalysis

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