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Filtering by: Funding statement These studies were supported by Natural Environment Research Council (UK) through grants GR3/8984 and GR9/583A (to J.T.). Academic Affiliation Chemistry

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:

Yang, Liping

Abstract:

The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....

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Dissertation

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). iii Finally, to complement our HDX studies, intrinsic fluorescence titration experiments were
Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Creator:

Zandkarimi, Fereshteh

Abstract:

State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...

Resource Type:

Dissertation

Full Text:

physiological processes and ultimately stages of diseases. This dissertation comprises research studies that

ScholarsArchive@OSU

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

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