Index Catalog // ScholarsArchive@OSU

Creator:: Yang, Liping
Abstract:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Resource Type:: Dissertation
Full Text:: group-mates, Shin-Cheng Tzeng and Sasidhar Nirudodhi for their kind advice. I also wish to thank other

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation
Full Text:: -Cheng Tzeng, Liping Yang, Fereshteh Zandkarimi, Ievgen Motorykin, Lin Huang, Soyoun Ahn, Juan Chavez

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Shin-Cheng Tzeng for the degree of Doctor of Philosophy in

Creator:: Vasil'ev, Yury V., Tzeng, Shin-Chen, Huang, Lin, and Maier, Claudia S.
Abstract:: The post-translational modification of proteins by electrophilic oxylipids is emerging as an important mechanism that contributes to the complexity of proteomes. Enzymatic and non-enzymatic oxidation of biological lipids results in the formation of chemically diverse electrophilic carbonyl compounds, such as 2-alkenals and 4-hydroxy alkenals, epoxides and eicosanoids with reactive cyclopentenone...
Resource Type:: Article

ScholarsArchive@OSU