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Filtering by: Creator White, Carole L. Academic Affiliation Chemistry

Total synthesis of the marine toxin phorboxazole A using palladium(II)-mediated intramolecular alkoxycarbonylation for tetrahydropyran synthesis

Creator:

Kuntiyong, Punlop, Lee, Tae Hee, Kranemann, Christian L., and White, James D.

Abstract:

The potent antitumor agent phorboxazole A was synthesized from six subunits comprising C1-C2 (115), C3-C8 (98), C9-C19 (74), C20-C32 (52), C33-C41 (84) and C42-C46 (85). Tetrahydropyrans B and C containing cis-2,6-disubstitution were fabricated via palladium(II)-mediated intramolecular alkoxycarbonylation which, in the case of tetrahydropyran C, was carried out with catalytic palladium(II)...

Resource Type:

Article

Full Text:

alkoxycarbonylation for tetrahydropyran synthesis Punlop Kuntiyong, Tae Hee Lee, Christian L. Kranemann and James D