Index Catalog // ScholarsArchive@OSU

Target fragmentation in the interaction of relativistic heavy ions and protons with ¹⁸¹Ta

Creator:: Oertel, Christopher Paul
Abstract:: The production cross sections for a number of target fragments formed by the reactions of 42- and 21- GeV²⁰ Ne and 28 GeV p with ¹⁸¹Ta have been measured. The target fragment radioactivities were measured by off-line gamma-ray spectroscopy. Details of the measurement as well as the calculation of the...
Resource Type:: Masters Thesis
Full Text:: ions and protons with ¹8¹Ta AN ABSTRACT OF THE THESIS OF Christopher Paul Oertel for the degree of

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Creator:: Emerson, Christopher R.
Abstract:: Sulfoxide-ligand exchange (SLE) and asymmetric halogen-metal exchange (AHME) processes were separately examined for the enantioselective synthesis of functionalized alpha-haloalkylmetal (carbenoid) reagents. Carbenoids derived from SLE were used to effect stereospecific reagent-controlled homologation (StReCH) of boronic esters and those generated via AHME were engaged in Darzens-type chemistry with aldehydes. Abstract for...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE DISSERTATION OF Christopher R Emerson for the degree of Doctor of Philosophy in

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Creator:: Salih, M. Quamar
Abstract:: Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
Resource Type:: Dissertation
Full Text:: ! Etherification! ! ! ! Abstract!approved:! ______________________________________________________! Christopher

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Creator:: Ferreira, Andrew
Abstract:: The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
Resource Type:: Dissertation
Full Text:: Christopher M. Beaudry The first part of this manuscript is about the total synthesis of the Arundo

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Creator:: Kim, GilSoo
Abstract:: The first part of this manuscript is about the total synthesis of the aspidosperma alkaloids leuconoxine, melodinine E and mersicarpine. Our synthetic strategy used a radical translocation-conjugate addition cascade to construct the core of the natural product. Specifically, a vinyl radical was generated from the homolysis of the C–I bond...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Christopher M. Beaudry The first part of this manuscript is about the total synthesis of the

Stereocontrolled Synthesis of Allenes by Eliminative Cross-Coupling of Carbenoids

Creator:: Cao, Yang
Abstract:: The bimolecular reaction of two carbenoid species resulting in the formation of a carbon-carbon double bond (pi-system), referred to herein as carbenoid eliminative cross-coupling (CEXC), involves a series of three fundamental steps: (i) ate-complex formation (transmetalation), (ii) 1,2-metalate rearrangement, and (iii) beta-elimination. All three steps are stereospecific and so the...
Resource Type:: Dissertation
Full Text:: Paul R. Blakemore The bimolecular reaction of two carbenoid species resulting in the formation

The development of aminal radicals for the synthesis of nitrogen-rich natural products

Creator:: Schiedler, David A.
Abstract:: Organic compounds which contain one or more nitrogen atoms are especially important as they are disproportionately represented among biologically active molecules. As a result, significant effort has been focused on the development of methods for the synthesis of nitrogenous molecules. We identified the aminal as an under-explored functional group. Despite...
Resource Type:: Dissertation
Full Text:: . Abstract approved: ______________________________________________________ Christopher M. Beaudry

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Creator:: Vellucci, Jessica K.
Abstract:: Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Christopher M. Beaudry Aminal radical intermediates were generated by the method of

Total Synthesis of Cephalotaxus Alkaloids and Synthetic Studies toward Bazzanin K

Creator:: Ju, Xuan
Abstract:: Dearomatization reactions exist broadly in biosynthesis and chemical synthesis. The highly functionalized atoms of arenes can be masked by it aromaticity, and upon dearomatization, those reactive atoms can be readily applied to bond formation and further manipulation. The total synthesis of (–)-cephalotaxine and (–)- homoharringtonine is described via an oxidative...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Christopher M. Beaudry Dearomatization reactions exist broadly in biosynthesis and chemical

Regioselective Synthesis of Substituted Phenols, Benzenes, Benzofuranones and Benzofurans and Synthesis of Homoharringtonine Analogs

Creator:: Zhang, Xiaojie
Abstract:: Substituted phenols are important substructures for pharmaceuticals, agrochemicals, natural products and biological probe molecules. The properties of phenolic molecules are substantially influenced by the substitution patterns of the phenolic ring. The chemical synthesis of phenols with various substitution patterns is an enduring challenge and multiple strategies have emerged. However, some...
Resource Type:: Dissertation

ScholarsArchive@OSU

Target fragmentation in the interaction of relativistic heavy ions and protons with ¹⁸¹Ta

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Stereocontrolled Synthesis of Allenes by Eliminative Cross-Coupling of Carbenoids

The development of aminal radicals for the synthesis of nitrogen-rich natural products

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Total Synthesis of Cephalotaxus Alkaloids and Synthetic Studies toward Bazzanin K

Regioselective Synthesis of Substituted Phenols, Benzenes, Benzofuranones and Benzofurans and Synthesis of Homoharringtonine Analogs

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