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Filtering by: Has journal Molecular Therapy - Nucleic Acids Remove constraint Has journal: Molecular Therapy - Nucleic Acids Academic Affiliation College of Pharmacy Remove constraint Academic Affiliation: College of Pharmacy Committee Member Mahmud, Taifo Remove constraint Committee Member: Mahmud, Taifo

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  • Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

    Creator:
    Blanchard, David, L.
    Abstract:
    L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
    Resource Type:
    Dissertation
    Full Text:
    18, 2008. Title: Advanced Studies on Cyclic Amino Acids Involved in GABAergic Neurotransmission

  • Ascorbylation- the biological relevance of covalently bound ascorbic acid

    Creator:
    Kesinger, Nicholas G.
    Abstract:
    Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
    Resource Type:
    Dissertation
    Full Text:
    . Title: Ascorbylation- the Biological Relevance of Covalently Bound Ascorbic Acid. Abstract

  • Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

    Creator:
    Zhang, Lingjuan
    Abstract:
    COUP-TFI, an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily, plays important roles in homeostasis and the CNS development, including differentiation, patterning, axonal projection, cell migration, cortical arealization and the temporal specification of neural stem cells. A number of COUP-interacting proteins have been described previously, and the majority of...
    Resource Type:
    Dissertation
    Full Text:
    presented on June 5, 2009 . Title: Deciphering the Molecular Mechanisms of the Transcriptional

  • Identification and quantitation of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in vivo as biomarkers of oxidative stress

    Creator:
    Kuiper, Heather C.
    Abstract:
    Oxidative stress occurs when the balance between reactive oxygen species and antioxidant defense mechanisms in the body becomes tipped heavily in favor of the reactive oxygen species. Reactive oxygen species can be present in excess due to elevated O2 levels, radiation, infection, smoking, or even excessive exercise. It is also...
    Resource Type:
    Dissertation
    Full Text:
    -193 19. Lovell, M. A., and Markesbery, W. R. (2007) Nucleic Acids Res. 35(22), 7497- 7504 20. Doorn

  • Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

    Creator:
    Fernandes, Roberta P. M.
    Abstract:
    In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
    Resource Type:
    Dissertation
    Full Text:
    acids residues shown to be in the DXR active site in the available E. coli crystal structures were also

  • Regulation of BCL11B by post-translational modifications

    Creator:
    Liu, Xiao
    Abstract:
    Bcl11b (B-cell lymphoma/leukemia 11b), also known as Ctip2 (Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2), is a C2H2 zinc finger transcriptional regulatory protein, which is an essential protein for post-natal life in the mouse and plays crucial roles in the development, and presumably function, of several organ systems,...
    Resource Type:
    Masters Thesis
    Full Text:
    may contribute to a better understanding of the molecular and cellular basis for Bcl11b function in

  • Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

    Creator:
    Vining, Oliver B.
    Abstract:
    Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
    Resource Type:
    Dissertation
    Full Text:
    synthesized the 2-amino-3-octanoic acid standards used to determine the absolute configuration of

  • Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

    Creator:
    Baarda, Benjamin I.
    Abstract:
    Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
    Resource Type:
    Dissertation
    Full Text:
    3-1. Amino acid identity of MlaA homologs. .............................................. 67 Table

  • Investigation of unique marine environments for microbial natural products

    Creator:
    Thornburg, Christopher C.
    Abstract:
    Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
    Resource Type:
    Dissertation
    Full Text:
    , ..................cytotoxicity data, molecular target or mechanism of action is listed. 8 Figure 2.1. Phylogenetic relationship

  • Biosynthetic studies of fungal diterpene antibiotics

    Creator:
    Yao, Qingmei
    Abstract:
    The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
    Resource Type:
    Masters Thesis
    Full Text:
    and nucleic acids that are essential for living organisms. Secondary metabolites are substances that