Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Committee Member Gombart, Adrian Academic Affiliation College of Pharmacy Committee Member Proteau, Philip

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:

Hardardt, Elizabeth Ann

Abstract:

This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...

Resource Type:

Masters Thesis

Full Text:

” Rochefort, Phil Proteau and Adrian “Fritz” Gombart, and all the researchers who developed the use of
Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

Creator:

Sheng, Yan

Abstract:

The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...

Resource Type:

Dissertation

Full Text:

Proteau, Dr. Jane Ishmael and Dr. Adrian Gombart for their generous time, support, advice and