Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Berman, T. Academic Affiliation College of Pharmacy Committee Member Schimerlik, Michael

Effects of quinolinate and nitro-, or thio- substituted analogs of quinolinate on glutamate receptor-mediated neurotoxicity in cerebellar granule cell cultures

Creator:

Zhang, Jinying

Abstract:

Quinolinate (QUIN) is an endogenous neurotoxic product of the kynurenine pathway of tryptophan metabolism. Quinolinate is a selective agonist of the NMDA family of glutamate receptors and, as such, may play a role in the pathology of a number of major central nervous system (CNS) disorders. These include both chronic...

Resource Type:

Masters Thesis

Full Text:

(Goldberg et al., 1987; Shalaby et al., 1989; Priestley, 1990; Berman and Murray, 1996). We chose
Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:

Han, Bingnan

Abstract:

This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...

Resource Type:

Dissertation

Full Text:

-, monohydrochloride t Triplet TEA Trifluoroacetic acid TOCSY Total Correlation Spectroscopy tR Retention Time Tyr