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Filtering by: Committee Member Gombart, Adrian Remove constraint Committee Member: Gombart, Adrian Academic Affiliation College of Pharmacy Remove constraint Academic Affiliation: College of Pharmacy Decade 2010-2019 Remove constraint Decade: 2010-2019

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  • The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

    Creator:
    Hardardt, Elizabeth Ann
    Abstract:
    This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
    Resource Type:
    Masters Thesis
    Full Text:
    ” Rochefort, Phil Proteau and Adrian “Fritz” Gombart, and all the researchers who developed the use of

  • A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

    Creator:
    Schumann, Canan B.
    Abstract:
    Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
    Resource Type:
    Dissertation

  • Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

    Creator:
    Sheng, Yan
    Abstract:
    The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
    Resource Type:
    Dissertation
    Full Text:
    Proteau, Dr. Jane Ishmael and Dr. Adrian Gombart for their generous time, support, advice and

  • Regulation of BCL11B by post-translational modifications

    Creator:
    Liu, Xiao
    Abstract:
    Bcl11b (B-cell lymphoma/leukemia 11b), also known as Ctip2 (Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2), is a C2H2 zinc finger transcriptional regulatory protein, which is an essential protein for post-natal life in the mouse and plays crucial roles in the development, and presumably function, of several organ systems,...
    Resource Type:
    Masters Thesis
    Full Text:
    . Filtz, Dr. Taifo Mahmud, and Dr. Adrian F. Gombart for serving on my committee and for their advice