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Filtering by: Creator Wess, Robert Academic Affiliation College of Pharmacy Date 2017

Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

Creator:

Nazari, Mohamad

Abstract:

Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...

Resource Type:

Dissertation

Full Text:

. L.; Edrada-Ebe R.; Quinn, R. J. Nature Rev. Drug. Discov. 2015, 14, 111-129. 6. Wess, G