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Filtering by: Academic Affiliation College of Pharmacy Date issued sim 2010-03

Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel

Creator:

Alani, Adam W. G., Bae, Younsoo, Rao, Deepa A., and Kwon, Glen S.

Abstract:

Poly(ethylene glycol)-block-poly(aspartate-hydrazide) (PEG-p(Asp-Hyd)) was modified using either levulinic acid (LEV) or 4-acetyl benzoic acid (4AB) attached via hydrazone bonds. Paclitaxel (PTX) conjugated to the linkers formed PEG-p(Asp-Hyd-LEV-PTX) and PEG-p(Asp-Hyd-4AB-PTX). PEG-p(Asp-Hyd-LEV-PTX) and PEG-p(Asp-Hyd-4AB-PTX) assemble into unimodal polymeric micelles with diameters of 42 nm and 137 nm, respectively. PEG-p(Asp-Hyd-LEV-PTX) and PEG-p(Asp-Hyd-4AB-PTX) at...

Resource Type:

Article