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Characterization of Selective Knockout of Thioredoxin Reductase-1 (TR1) in Mouse Melanocytes In Vivo

Creator:

Wyant, Mark B.

Abstract:

Vitiligo is a disease characterized by depigmented patches of skin. The disease is known to involve the loss of melanocytes in the basal layer of the skin in affected areas, but the underlying mechanisms are unknown. Recent evidence suggests oxidative stress and disruptions to antioxidant pathways contribute to an autoimmune...

Resource Type:

Undergraduate Thesis

Full Text:

the phenotype and a prediction of the genotype made prior to genotyping. Mice that exhibited a