Index Catalog // ScholarsArchive@OSU

Creator:: Sabry, Omar Mohamed
Abstract:: This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Resource Type:: Dissertation
Full Text:: channel blocking activity (EC = 0.3 and 0.9 pg/mi, respectively). Stypoaldehyde, as well as the previously

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: enzyme acetoacetyl-CoA thiolase (EC 2.3.1.9) to produce acetoacetyl-CoA. In the second step, 3-hydroxy-3

Creator:: Tehan, Richard M.
Abstract:: Since the discovery of penicillin in 1928, the fungal kingdom has remained a fertile source for the discovery of new, biologically active, natural products. Further, as natural products continue to be discovered from fungi, a deeper understanding of the critical role of specialized metabolism in fungal ecology is afforded. The...
Resource Type:: Dissertation

Creator:: Chou, Joyce Tian-wei
Resource Type:: Dissertation
Full Text:: ® lotion; (0) OFF! ® spray 95; () Cutter® cream; (0) Ultrathom® cream; (A) REPEL® aerosol; (EC Cutter

Creator:: Phaosiri, Chanokporn
Abstract:: The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
Resource Type:: Dissertation
Full Text:: - diphosphate decarboxylase; vii, IPP isomerase. 7 A NADPH-dependent HMG-CoA reductase (EC 1.1.1.34

Creator:: Nagle, Dale George
Abstract:: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
Resource Type:: Dissertation
Full Text:: DMSO Dimethylsulfoxide EC Effective Concentration EI Electron Impact EtOAc Ethyl Acetate FAB Fast

ScholarsArchive@OSU