Index Catalog // ScholarsArchive@OSU

Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

Creator:: Baarda, Benjamin I.
Abstract:: Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
Resource Type:: Dissertation
Full Text:: challenged by the gonococcus’s tremendous modulation of its surface proteome, evasion of immune responses

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Creator:: Wierzbicki, Igor H.
Abstract:: The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Resource Type:: Dissertation

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:: Carpenter, Evan L.
Abstract:: Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Resource Type:: Dissertation
Full Text:: proteome following NRF2 modulation revealed that inhibition of NRF2 expression led to changes in the

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Creator:: Wan, Xuemei
Abstract:: Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...
Resource Type:: Dissertation
Full Text:: . Science, 2009. 324(5930): p. 1029-33. 15 34. Wang, W. and K.L. Guan, AMP-activated protein

Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

Creator:: Newman, Nolan K.
Abstract:: The gut microbiome has been previously implemented in a number of diseases. Of note is its substantial role in metabolic syndrome, which encapsulates a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and stroke. Understanding the causal relationships between the gut microbiome and host processes...
Resource Type:: Dissertation

Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

Creator:: Selman, Wisam H.
Abstract:: Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...
Resource Type:: Dissertation

Studies on the ecological functions of the antidiabetic drugs acarbose

Creator:: Tanoeyadi, Samuel
Abstract:: Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature. Many secondary metabolites isolated from plants and microbes have found use as molecular probes, drug leads, or medicine...
Resource Type:: Masters Thesis
Full Text:: degree of Master of Science in Pharmaceutical Sciences Presented on April 28, 2023 Title: Studies on

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: . Comprehensive Reviews in Food Science and Food Safety 15: 542-567. 15. Koetter, U., and M. Biendl. 2010

Natural Products Discovery from Unique Microbial Habitats

Creator:: Gallegos, David A.
Abstract:: Marine natural products possess an abundance of diverse chemical scaffolds with unique biological activities. By targeting unusual or unique microbial environments within varying marine ecologies we can continue to discover novel chemistry with potentially new molecular targets. The research presented here is focused on exploring unusual chemical ecologies and the...
Resource Type:: Dissertation

Development and broad application of a mass spectrometry based metabolomics platform

Creator:: Kirkwood, Jay Steven
Abstract:: Metabolomics is a comprehensive analysis of small molecules, or metabolites, in a system. Metabolomics is a hypothesis-generating experiment and offers an unbiased analysis of cell metabolism that can aid in the understanding of fundamental biological processes. Metabolomics is widely and broadly applicable in the biological sciences and has been used...
Resource Type:: Dissertation

ScholarsArchive@OSU

Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

Studies on the ecological functions of the antidiabetic drugs acarbose

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Natural Products Discovery from Unique Microbial Habitats

Development and broad application of a mass spectrometry based metabolomics platform

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