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Filtering by: Has journal Journal of Alloys and Compounds Academic Affiliation College of Pharmacy License Attribution 3.0 United States

The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster

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Bushley, Kathryn E., Raja, Rajani, Jaiswal, Pankaj, Cumbie, Jason S., Nonogaki, Mariko, Boyd, Alexander E., Owensby, C. Alisha, Knaus, Brian J., Elser, Justin, Miller, Daniel, Di, Yanming, McPhail, Kerry L., and Spatafora, Joseph W.

Abstract:

The ascomycete fungus Tolypocladium inflatum, a pathogen of beetle larvae, is best known as the producer of the immunosuppressant drug cyclosporin. The draft genome of T. inflatum strain NRRL 8044 (ATCC 34921), the isolate from which cyclosporin was first isolated, is presented along with comparative analyses of the biosynthesis of...

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: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster Kathryn E. Bushley1
Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

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Hau, Andrew M., Greenwood, Jeffrey A., Lohr, Christiane V., Serrill, Jeffrey D., Proteau, Philip J., Ganley, Ian G., McPhail, Kerry L., and Ishmael, Jane E.

Abstract:

Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...

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a potent anti-proliferative response and ‘‘COMPARE-negative’’ profile indicative of a unique

ScholarsArchive@OSU

The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

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