Index Catalog // ScholarsArchive@OSU

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Creator:: Hau, Andrew M., Greenwood, Jeffrey A., Lohr, Christiane V., Serrill, Jeffrey D., Proteau, Philip J., Ganley, Ian G., McPhail, Kerry L., and Ishmael, Jane E.
Abstract:: Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
Resource Type:: Article
Full Text:: mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was

BCL11B Regulates Epithelial Proliferation and Asymmetric Development of the Mouse Mandibular Incisor

Creator:: Kyrylkova, Kateryna, Kyryachenko, Sergiy, Biehs, Brian, Klein, Ophir, Kioussi, Chrissa, and Leid, Mark
Abstract:: Mouse incisors grow continuously throughout life with enamel deposition uniquely on the outer, or labial, side of the tooth. Asymmetric enamel deposition is due to the presence of enamel-secreting ameloblasts exclusively within the labial epithelium of the incisor. We have previously shown that mice lacking the transcription factor BCL11B/CTIP2 (BCL11B...
Resource Type:: Article
Full Text:: hereafter) exhibit severely disrupted ameloblast formation in the developing incisor. We now report that

Analysis and Expansion of the Role of the Escherichia coli Protein ProQ

Creator:: Sheidy, Daniel T. and Zielke, Ryszard A.
Abstract:: The decrease in proline transport by the proline porter ProP in a Delta proQ strain has been well documented; however, the reason for this phenotype remains undefined. Previous studies have speculated that ProQ facilitates translation of proP mRNA. Here, we demonstrate that ProQ is enriched in the polysome fractions of...
Resource Type:: Article
Full Text:: translating ribosomes, and deletion of proP in combination with the proU operon has no effect on ProQ

Population-Specific Regulation of Chmp2b by Lbx1 during Onset of Synaptogenesis in Lateral Association Interneurons

Creator:: Xu, Jun, Nonogaki, Mariko, Madhira, Ravi, Ma, Hsiao-Yen, Hermanson, Ola, Kioussi, Chrissa, and Gross, Michael K.
Abstract:: Chmp2b is closely related to Vps2, a key component of the yeast protein complex that creates the intralumenal vesicles of multivesicular bodies. Dominant negative mutations in Chmp2b cause autophagosome accumulation and neurodegenerative disease. Loss of Chmp2b causes failure of dendritic spine maturation in cultured neurons. The homeobox gene Lbx1 plays...
Resource Type:: Article
Full Text:: AR054406 to Chrissa Kioussi. URL of the funder: http://www.niams.nih.gov/ default.asp. The funders had no

Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm

Creator:: Eng, Diana, Ma, Hsiao-Yen, Xu, Jun, Shih, Hung-Ping, Gross, Michael K., and Kiouss, Chrissa
Abstract:: Correction 17 Oct 2012: Eng D, Ma HY, Xu J, Shih HP, Gross MK, et al. (2012) Correction: Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm. PLOS ONE 7(10): 10.1371/annotation/c980d5a1-1899-4d30-af7b-573d4049cf4b
Resource Type:: Article
Full Text:: : This research was supported by NIH-NIAMS grant AR054406 to CK. The funders had no role in study design

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Creator:: Cavalier, Michael C., Yim, Young-Sun, Asamizu, Shumpei, Neau, David, Almabruk, Khaled H., Mahmud, Taifo, and Lee, Yong-Hwan
Abstract:: The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of...
Resource Type:: Article
Full Text:: supported by grants from the National Institutes of Health (R01 AI061528) (www.nih.gov). The funders had no

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Creator:: Wang, Zhixing, Zhang, Ling-juan, Guha, Gunjan, Li, Shan, Kyrylkova, Kateryna, Kioussi, Chrissa, Leid, Mark, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Background: Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal differentiation, as well as altered lipid composition during development. However, little is known about the role of Ctip2...
Resource Type:: Article
Full Text:: Environmental Health Sciences Center, Oregon State University. The funders had no role in study design, data

Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

Creator:: Liang, Xiaobo, Bhattacharya, Shreya, Bajaj, Gaurav, Guha, Gunjan, Wang, Zhixing, Jang, Hyo-Sang, Leid, Mark, Indra, Arup Kumar, and Ganguli-Indra, Gitali
Abstract:: Background: COUP-TF interacting protein 2 [(Ctip2), also known as Bcl11b] is an important regulator of skin homeostasis, and is overexpressed in head and neck cancer. Ctip2(ep-/-) mice, selectively ablated for Ctip2 in epidermal keratinocytes, exhibited impaired terminal differentiation and delayed epidermal permeability barrier (EPB) establishment during development, similar to what...
Resource Type:: Article
Full Text:: no role in study design, data collection and analysis, decision to publish, or preparation of the

The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster

Creator:: Bushley, Kathryn E., Raja, Rajani, Jaiswal, Pankaj, Cumbie, Jason S., Nonogaki, Mariko, Boyd, Alexander E., Owensby, C. Alisha, Knaus, Brian J., Elser, Justin, Miller, Daniel, Di, Yanming, McPhail, Kerry L., and Spatafora, Joseph W.
Abstract:: The ascomycete fungus Tolypocladium inflatum, a pathogen of beetle larvae, is best known as the producer of the immunosuppressant drug cyclosporin. The draft genome of T. inflatum strain NRRL 8044 (ATCC 34921), the isolate from which cyclosporin was first isolated, is presented along with comparative analyses of the biosynthesis of...
Resource Type:: Article
Full Text:: had no role in study design, data collection and analysis, decision to publish, or preparation of the

Regulation of Motility of Myogenic Cells in Filling Limb Muscle Anlagen by Pitx2

Creator:: Campbell, Adam L., Shih, Hung-Ping, Xu, Jun, Gross, Michael K., and Kioussi, Chrissa
Abstract:: Cells of the ventrolateral dermomyotome delaminate and migrate into the limb buds where they give rise to all muscles of the limbs. The migratory cells proliferate and form myoblasts, which withdraw from the cell cycle to become terminally differentiated myocytes. The myogenic lineage colonizes pre-patterned regions to form muscle anlagen...
Resource Type:: Article
Full Text:: AR054406 to CK. The funders had no role in study design, data collection and analysis, decision to publish

ScholarsArchive@OSU

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

BCL11B Regulates Epithelial Proliferation and Asymmetric Development of the Mouse Mandibular Incisor

Analysis and Expansion of the Role of the Escherichia coli Protein ProQ

Population-Specific Regulation of Chmp2b by Lbx1 during Onset of Synaptogenesis in Lateral Association Interneurons

Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster

Regulation of Motility of Myogenic Cells in Filling Limb Muscle Anlagen by Pitx2

Limit your search

Academic Affiliation

Creator

Date

Decade

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Search Constraints

Search Results

Limit your search