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Filtering by: Committee Member Gombart, Adrian Academic Affiliation College of Pharmacy Subject Biotransformation (Metabolism)

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:

Hardardt, Elizabeth Ann

Abstract:

This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...

Resource Type:

Masters Thesis

Full Text:

” Rochefort, Phil Proteau and Adrian “Fritz” Gombart, and all the researchers who developed the use of