Index Catalog // ScholarsArchive@OSU

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: , Dr. Kathy Magnusson, and Dr. David Williams for their guidance and encouragement. I would also

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Creator:: Vyshenska, Dariia
Abstract:: Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
Resource Type:: Dissertation
Full Text:: grateful to my committee members, Stephen Ramsey, Jane Ishmael, and Kathy Magnusson for their vital

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Creator:: Wan, Xuemei
Abstract:: Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...
Resource Type:: Dissertation
Full Text:: Magnusson as well, for their time and assistance during this process. I would like to acknowledge the

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Creator:: Hau, Andrew M.
Abstract:: Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Resource Type:: Dissertation
Full Text:: . Schafer KA (1998) The cell cycle: a review. Vet Pathol 35: 461-478. 14. Williams GH, Stoeber K (2012) The

Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

Creator:: Hoyt, Dale G.
Abstract:: BCNU caused severe cholestasis in rats after a single intraperitoneal injection. The cholestasis was characterized by a selective reduction of the bile salt independent bile flow to 11% of control. Decreased food or water consumption by the treated rats apparently did not contribute to cholestasis. Measurements of plasma Na⁺ and...
Resource Type:: Masters Thesis
Full Text:: treated rats apparently did not contribute to cholestasis. Measurements of plasma Na + and K

Transdermal Delivery of Atenolol to Cats

Creator:: Mohamed, Sumeia M.
Abstract:: This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
Resource Type:: Dissertation

Pharmacokinetics of Flunixin in Elephants, Cefovecin in African Lions, and Gamithromycin in Alpacas

Creator:: Alshahrani, Sultan M.
Abstract:: Foot pathology is a real problem in captive elephants. Osteoarthritis is the major concern among musculoskeletal disorders and foot health problems for elephants in North America zoos with one-‐half of Elephants in captivity showing foot health care problems in zoos. A higher ratio of captive Asian elephants (Elephas maximus) is...
Resource Type:: Dissertation

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: randomized controlled trials. Medicine 95. 4. Bray, G. A., K. K. Kim, J. P. H. Wilding, and F. on behalf

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Creator:: Schumann, Canan B.
Abstract:: Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
Resource Type:: Dissertation
Full Text:: Jr., MD, Ronald D. Alvarez, MD, Deborah K. Armstrong, MD, Barry Boston, MD, Robert A. Burger, MD

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

Creator:: Hoyt, Dale G.
Abstract:: Previous investigation showed that 20 mg/kg BCNU caused inhibition of sulfobromophthalein (BSP) excretion and inhibited bile salt independent bile flow (BSIF) in rats by 48 h after treatment (Hoyt, 1984). The present investigation demonstrated that BCNU inhibited the canalicular step in the excretion of BSP. This was indicated by the...
Resource Type:: Dissertation

ScholarsArchive@OSU

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

Transdermal Delivery of Atenolol to Cats

Pharmacokinetics of Flunixin in Elephants, Cefovecin in African Lions, and Gamithromycin in Alpacas

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

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