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Filtering by: Subject Antibiotics -- Synthesis Remove constraint Subject: Antibiotics -- Synthesis Academic Affiliation College of Pharmacy Remove constraint Academic Affiliation: College of Pharmacy

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  • Biosynthesis and Rational Design of Novel Pactamycin Analogs

    Creator:
    Abugrain, Mostafa E.
    Abstract:
    Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
    Resource Type:
    Dissertation
    Full Text:
    Mahmud Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomyces

  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    , 2012. Title: Biosynthesis and Modification of the Antibiotic Enduracidin Abstract approved: T. Mark

  • Biosynthetic studies of fungal diterpene antibiotics

    Creator:
    Yao, Qingmei
    Abstract:
    The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
    Resource Type:
    Masters Thesis
    Full Text:
    Pleurotus passeckerianus Pilat Antibiotic compounds………………………………………… 31 Introduction to

  • Formation and modification of enduracididine, a nonproteinogenic amino acid

    Creator:
    Tan, Ying
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. In this thesis, we studied the formation and modification of the nonproteinogenic amino acid enduracididine (End), which exists in two important antibiotics, mannopeptimycins (MPPs) and enduracidin. Sequence analysis of the MPP gene cluster revealed that the product of...
    Resource Type:
    Masters Thesis
    Full Text:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. In