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Filtering by: Subject Anticonvulsants Remove constraint Subject: Anticonvulsants Academic Affiliation College of Pharmacy Remove constraint Academic Affiliation: College of Pharmacy

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Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

Creator:

Zhang, Ge

Abstract:

Although considerable experimental evidence suggests that endogenous adenosine may function as a modulator of neuronal activity in the etiology or control of seizures, the neuroanatomical and neurochemical basis for the anticonvulsant actions of adenosine have not been well established. A discrete brain region of possible fundamental importance to epileptogenisis within...

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Masters Thesis

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and neurochemical basis for the anticonvulsant actions of adenosine have not been well established
Activation of adenosine receptors in prepiriform cortex modulates seizure susceptibility

Creator:

Zhang, Ge, 1956-

Resource Type:

Dissertation

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study was to characterize the anticonvulsant actions mediated by activation of the adenosine receptor
Adenosine receptor modulation of seizure susceptibility in rats

Creator:

Szot, Patricia

Abstract:

Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...

Resource Type:

Dissertation

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observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA
Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:

Blanchard, David, L.

Abstract:

L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...

Resource Type:

Dissertation

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Academic Affiliation

College of Pharmacy[remove]4

Advisor

Murray, Thomas F.3
Zabriskie, T. Mark1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 1988 to 2009

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Committee Member

Mahmud, Taifo1
Proteau, Philip, J.1
Savage, Thomas, F.1
Yin, Xihou1

Creator

Blanchard, David, L.1
Szot, Patricia1
Zhang, Ge1
Zhang, Ge, 1956 1

Date

Date range begin – Date range end

Current results range from 1987 to 2008

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Decade

2000-20091
1990-19991
1980-19892

Degree Field

Pharmacy4

Degree Level

Doctoral3
Master's1

Degree Name

Doctor of Philosophy (Ph.D.)3
Master of Science (M.S.)1

Language

English [eng]4

License

All rights reserved1

Non-Academic Affiliation

Oregon State University. Graduate School4

Peer Reviewed

No4

Resource Type

Dissertation3
Masters Thesis1

Rights Statement

Copyright Not Evaluated3
In Copyright1

Subject

Adenosine -- Physiological effect3
Adenosine -- Receptors3
Anticonvulsants3
Amino acid neurotransmitters1
Anticonvulsants -- Development1
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