Index Catalog // ScholarsArchive@OSU

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: bioavailability of dyphylline AN ABSTRACT OF THE THESIS OF Shyi-Feu Chang for the degree of Doctor of

Pseudoprogression of Glioblastoma after Chemo- and Radiation Therapy: Diagnosis by Using Dynamic Susceptibilityweighted Contrast-enhanced Perfusion MR Imaging with Ferumoxytol versus Gadoteridol and Correlation with Survival

Creator:: Gahramanov, Seymur, Muldoon, Leslie L., Varallyay, Csanad G., Li, Xin, Kraemer, Dale F., Fu, Rongwei, Hamilton, Bronwyn E., Rooney, William D., and Neuwelt, Edward A.
Abstract:: This file has been removed from the repository due to a DMCA Takedown Notice.
Resource Type:: Article
Full Text:: Csanad G. Varallyay, MD Xin Li, PhD Dale F. Kraemer, PhD Rongwei Fu, PhD Bronwyn E. Hamilton, MD William

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Creator:: Kim, Jeonghwan
Abstract:: Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
Resource Type:: Dissertation
Full Text:: selectively, we attempted to deliver therapeutic mRNA to treat lung diseases. Severe acute respiratory

Biochemical changes associated with BCNU-induced pulmonary toxicity

Creator:: Jarvi, Eric J.
Abstract:: Male Sprague Dawley rats received a single intraperitoneal dose of BCNU in experiments designed to measure biochemical changes associated with the pulmonary toxicity described for this agent. Changes in serum and lung lavage angiotensin converting enzyme (ACE) activity were measured to detect changes in pulmonary endothelial cell integrity. Alpha-1-proteinase inhibitor...
Resource Type:: Dissertation
Full Text:: pulmonary toxicity described for this agent. Changes in serum and lung lavage angiotensin converting enzyme

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: cytotoxicity to NCI-H460 human lung tumor and neuro-2a mouse neuroblastoma cells. Intriguingly, wewakpeptin A

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Creator:: Andrianasolo, Eric Hajaniriana
Abstract:: This thesis is an investigation of the natural products deriving from marine algae and cyanobacteria and has resulted in the discovery of eleven new secondary metabolites. The structure elucidations of these new molecules were performed using a variety of spectroscopic techniques. Four new macrolides were isolated and characterized from the...
Resource Type:: Dissertation
Full Text:: cytotoxicities ranging from 178 nM to 354 nM against human lung cancer (NCI-H460) and mouse neuro-2a cell

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Creator:: DuRoss, Allison N.
Abstract:: The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Resource Type:: Dissertation
Full Text:: . ............................................................................................................................. 118 Figure 2S8. Histologic identification of lung metastases

Boosting Intracellular Delivery of mRNA Therapeutics

Creator:: Patel, Siddharth D.
Abstract:: Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
Resource Type:: Dissertation
Full Text:: asthma and other lung diseases, enhance intracellular mRNA delivery in vitro (over 3-fold, p < 0.005

Rational vaccine development 1) Design of a Triantigen Nasal Anthrax Vaccine Candidate 2) A Novel Lecithin Based Nanoparticle as a Vaccine Delivery System

Creator:: Sloat, Brian R.
Abstract:: Currently, the only anthrax vaccine licensed for human use in the United States is the Anthrax-vaccine-absorbed (AVA or Biothrax®). AVA suffers from several drawbacks, including a complicated and lengthy dosing schedule that requires six initial injections administered over eighteen months, followed by annual boosters. Therefore, a new generation anthrax vaccine...
Resource Type:: Dissertation
Full Text:: friendship both in and out of the lab. I would like to thank Dr. Woongye Chung, Dr. Zhen Yu, Dr. Qui Fu

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Creator:: Serrill, Jeffrey D.
Abstract:: Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Resource Type:: Dissertation
Full Text:: rapid metabolic adaptation to apoptolidin A……………………………………………………………... 55 2.4 Human lung cancer cells

ScholarsArchive@OSU

New product formulations, pharmacokinetics and bioavailability of dyphylline

Pseudoprogression of Glioblastoma after Chemo- and Radiation Therapy: Diagnosis by Using Dynamic Susceptibilityweighted Contrast-enhanced Perfusion MR Imaging with Ferumoxytol versus Gadoteridol and Correlation with Survival

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Biochemical changes associated with BCNU-induced pulmonary toxicity

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Boosting Intracellular Delivery of mRNA Therapeutics

Rational vaccine development 1) Design of a Triantigen Nasal Anthrax Vaccine Candidate 2) A Novel Lecithin Based Nanoparticle as a Vaccine Delivery System

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

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