Index Catalog // ScholarsArchive@OSU

Nonmuscle myosins II-B and Va are components of detergentresistant membrane skeletons derived from mouse forebrain

Creator:: Ishmael, Jane E., Safic, Masa, Amparan, David, Vogel, Walter K., Pham, Tuyen, Marley, Kevin, Filtz, Theresa M., and Maier, Claudia S.
Abstract:: Myosins are actin-based molecular motors that may have specialized trafficking and contractile functions in cytoskeletal compartments that lack microtubules. The postsynaptic excitatory synapse is one such specialization, yet little is known about the spatial organization of myosin motor proteins in the mature brain. We used a proteomics approach to determine...
Resource Type:: Preprint and Article
Full Text:: neurotransmitter glutamate (Cheng et al. 2006; Collins et al. 2006). Myosins are protein complexes comprised of

Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

Creator:: Zhang, Ge
Abstract:: Although considerable experimental evidence suggests that endogenous adenosine may function as a modulator of neuronal activity in the etiology or control of seizures, the neuroanatomical and neurochemical basis for the anticonvulsant actions of adenosine have not been well established. A discrete brain region of possible fundamental importance to epileptogenisis within...
Resource Type:: Masters Thesis
Full Text:: potential amplitudes in the rat olfactory cortex slice via Al receptors (Collins et al., 1985). Direct

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:: Carpenter, Evan L.
Abstract:: Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Resource Type:: Dissertation

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Creator:: Vyshenska, Dariia
Abstract:: Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
Resource Type:: Dissertation

Modification of the acute effects of ethanol or acetaldehyde on drug metabolism by ascorbic acid, thiamine, or cysteine in vivo

Creator:: LaFollette, Sharron E.
Abstract:: The inhibition of mixed-function oxidase (MFO) activity by ethanol or acetaldehyde was examined in vivo by monitoring changes in salivary half-life of antipyrine or aminopyrine in adult male Sprague-Dawley rats. Ethanol (1-6 g/kg, po) or acetaldehyde (4-8 mmol/kg, ip) was administered 20 minutes prior to antipyrine (100 mg/kg, ip) or...
Resource Type:: Dissertation
Full Text:: (Collins, 1988). The purpose of this research is to select dietary factors which have demonstrated their

Bioadhesive polymers in drug product formulations

Creator:: Tavipatana, Wattanaporn
Abstract:: Gastric retention time of single unit dosage forms in swine was found to be much longer than in humans. It was concluded that swine are not a good animal model to study GI transit time of nonerodable or slowly eroded dosage forms. Noneradable and slowly eroded dosage forms used to...
Resource Type:: Dissertation

Activation of adenosine receptors in prepiriform cortex modulates seizure susceptibility

Creator:: Zhang, Ge, 1956-
Resource Type:: Dissertation
Full Text:: hippocampal pyramidal cells (Schubert and Lee, 1986). The postsynaptic actions of adenosine appear to be due

Formulation studies of lactic acid-producing bacteria for oral administration

Creator:: Liou, Yow-Hwa Grace
Abstract:: Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
Resource Type:: Dissertation

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: stroke (Choi et al., 1988; Lee et al., 1999). In addition, NMDA type glutamate 3 receptors has

ScholarsArchive@OSU

Nonmuscle myosins II-B and Va are components of detergentresistant membrane skeletons derived from mouse forebrain

Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Modification of the acute effects of ethanol or acetaldehyde on drug metabolism by ascorbic acid, thiamine, or cysteine in vivo

Bioadhesive polymers in drug product formulations

Activation of adenosine receptors in prepiriform cortex modulates seizure susceptibility

Formulation studies of lactic acid-producing bacteria for oral administration

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

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