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Filtering by: Alternative title ssim EC 1422 Academic Affiliation College of Pharmacy

New bioactive natural products from marine algae and cyanobacteria

Creator:

Sabry, Omar Mohamed

Abstract:

This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...

Resource Type:

Dissertation

Full Text:

channel blocking activity (EC = 0.3 and 0.9 pg/mi, respectively). Stypoaldehyde, as well as the previously
Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:

Carpenter, Evan L.

Abstract:

Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...

Resource Type:

Dissertation
Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:

Marquez, Brian L.

Abstract:

This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...

Resource Type:

Dissertation