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  • Formulation studies of lactic acid-producing bacteria for oral administration

    Creator:
    Liou, Yow-Hwa Grace
    Abstract:
    Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
    Resource Type:
    Dissertation
    Full Text:
    contents weight was 188.17 mg ± 7.5% for all seven lots. Enteric coated (EC) lactobacilli capsules were

  • Effect of pharmaceuticals and natural products on multidrug resistance mediatedtransport in Caco-2 and MDCKII-MDR1 drug transport models

    Creator:
    Fan, Ying
    Abstract:
    This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
    Resource Type:
    Dissertation

  • Investigation of unique marine environments for microbial natural products

    Creator:
    Thornburg, Christopher C.
    Abstract:
    Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
    Resource Type:
    Dissertation
    Full Text:
    ..........(FDA), European Commission (EC) or in various stages of clinical trial. 6 Figure 1.3. Examples of

  • Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

    Creator:
    Fernandes, Roberta P. M.
    Abstract:
    In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
    Resource Type:
    Dissertation
    Full Text:
    hydroxymethylglutaryl-CoA synthase [EC 2.3.3.10]. The next step is a reduction of the thioester of HMG-CoA providing

  • Studies on isoprenoid biosynthesis in Euglena gracilis

    Creator:
    Kim, Dojung
    Abstract:
    This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
    Resource Type:
    Dissertation
    Full Text:
    enzyme acetoacetyl-CoA thiolase (EC 2.3.1.9) to produce acetoacetyl-CoA. In the second step, 3-hydroxy-3

  • Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

    Creator:
    Hoyt, Dale G.
    Abstract:
    BCNU caused severe cholestasis in rats after a single intraperitoneal injection. The cholestasis was characterized by a selective reduction of the bile salt independent bile flow to 11% of control. Decreased food or water consumption by the treated rats apparently did not contribute to cholestasis. Measurements of plasma Na⁺ and...
    Resource Type:
    Masters Thesis
    Full Text:
    dehydrogenase (EC 1.1.1.50), and beta-nicotinamide adenine dinucleotide (oxidized). Ethylenediaminetetraacetic

  • Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

    Creator:
    Phaosiri, Chanokporn
    Abstract:
    The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
    Resource Type:
    Dissertation
    Full Text:
    - diphosphate decarboxylase; vii, IPP isomerase. 7 A NADPH-dependent HMG-CoA reductase (EC 1.1.1.34

  • Regulation of inositol phospholipid hydrolysis by extended treatment with angiotensin II in human aortic smooth muscle cells

    Creator:
    Niibori, Yoshiko
    Abstract:
    Long-term stimuli of many systems leads to decreased cellular responsiveness, or desensitization. We characterized the desensitization of angiotensin II (Ang 11)-mediated inositol phospholipid (IP) hydrolysis in cultured human aortic smooth muscle cells (HASMC). Although it has been suggested that the desensitization induced by long-term Mg II exposure may result partially...
    Resource Type:
    Masters Thesis

  • Biologically active cyclic depsipeptides from marine cyanobacteria

    Creator:
    Medina, Rebecca A.
    Abstract:
    This thesis describes the chemical investigation of marine cyanobacteria collected in Madagascar and Panama with an emphasis on the isolation and structure elucidation of medicinally relevant secondary metabolites. A collection of the marine cyanobacterium Lyngbya majuscula from the Radames Islands, Madagascar yielded two new cyclic depsipeptides, radamamides A and B,...
    Resource Type:
    Dissertation
    Full Text:
    (Aplidin®, 6) have been granted orphan drug status by the European Commission 333 and U.S. Federal

  • Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

    Creator:
    Han, Bingnan
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
    Resource Type:
    Dissertation
    Full Text:
    is a blocker of voltage-sensitive Na channel in mouse neuro-2a cells (EC = 1 nM). In an inflammatory