Index Catalog // ScholarsArchive@OSU

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Creator:: Andrianasolo, Eric Hajaniriana
Abstract:: This thesis is an investigation of the natural products deriving from marine algae and cyanobacteria and has resulted in the discovery of eleven new secondary metabolites. The structure elucidations of these new molecules were performed using a variety of spectroscopic techniques. Four new macrolides were isolated and characterized from the...
Resource Type:: Dissertation
Full Text:: Dimethylsulfoxide DNMT-1 DNA Methyltransferase 1 EC Effective Concentration EDTA Ethylenediaminetetraacetic

1) Improving the Uptake and Retention of Gadolinium in Tumors for Potential Gadolinium-Neutron Capture Therapy. 2) Integration of Gemcitabine or Localized Irradiation into dsRNA Therapy Significantly Enhanced the Resultant Anti-tumor Activity

Creator:: Le, Uyen Minh
Abstract:: Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...
Resource Type:: Dissertation

Biologically active cyclic depsipeptides from marine cyanobacteria

Creator:: Medina, Rebecca A.
Abstract:: This thesis describes the chemical investigation of marine cyanobacteria collected in Madagascar and Panama with an emphasis on the isolation and structure elucidation of medicinally relevant secondary metabolites. A collection of the marine cyanobacterium Lyngbya majuscula from the Radames Islands, Madagascar yielded two new cyclic depsipeptides, radamamides A and B,...
Resource Type:: Dissertation
Full Text:: addition, ET-743 was granted orphan drug status from the European Commission (EC) and the U.S. Food and

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:: Han, Bingnan
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...
Resource Type:: Dissertation
Full Text:: anticancer natural products are ecteinascidin 743 (10) and bryostatin 1 (11) (Tablel. I). The marine

1) Preparation of Acetaminophen Capsules Containing Beads Prepared by Hot-melt Direct Blend Coating Method 2) Pharmacokinetic Modeling and Monte Carlo Simulations in The Context of Additional Criteria for Bioequivalence Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to Tendinopathy

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation

New bioactive natural products from marine algae and cyanobacteria

Creator:: Sabry, Omar Mohamed
Abstract:: This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
Resource Type:: Dissertation
Full Text:: agent that is currently in phase Ill clinical trial is ecteinascidin 743 (11 ),22 isolated from the

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Creator:: Rakkanka, Vipaporn
Abstract:: This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
Resource Type:: Dissertation

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Creator:: Nogle, Lisa Marie
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
Resource Type:: Dissertation
Full Text:: Doublet DHiv Dihydroxyisovaleric acid DMSO Dimethylsulfoxide EC Effective Concentration EtOAc Ethyl

Prevalance [sic] of senile dementia of the Alzheimer type (SDAT) in females receiving postmenopausal conjugated estrogen vs. controls : a retrospective review

Creator:: Gooch, Michael D.
Abstract:: Recent in vitro data provide evidence that estrogen may assist in the maintenance of nervous tissue viability. Anecdotal reports suggest a lower prevalence of SDAT in postmenopausal women who have received estrogen replacement therapy although published data are conflicting. The purposes of this study are to determine whether the incidence...
Resource Type:: Masters Thesis

ScholarsArchive@OSU

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

1) Improving the Uptake and Retention of Gadolinium in Tumors for Potential Gadolinium-Neutron Capture Therapy. 2) Integration of Gemcitabine or Localized Irradiation into dsRNA Therapy Significantly Enhanced the Resultant Anti-tumor Activity

Biologically active cyclic depsipeptides from marine cyanobacteria

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

New bioactive natural products from marine algae and cyanobacteria

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Prevalance [sic] of senile dementia of the Alzheimer type (SDAT) in females receiving postmenopausal conjugated estrogen vs. controls : a retrospective review

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