Index Catalog // ScholarsArchive@OSU

Creator:: Yu, Yupei
Abstract:: Nalidixic acid and its derivatives act through inhibition of bacterial DNA gyrase activity. Recently there have been a series of papers reporting the antibacterial activity against three different types of bacteria (S. aureus, E. coli and P. aeruginosa) by a series of 1,4-dihydro-4-oxoquinoline (or 1,8-naphthyridine) 3-carboxylic acids. Consistent biological data...
Resource Type:: Masters Thesis

Creator:: Ali, Seham A.
Abstract:: An in vitro labeling procedure was developed based on optimal conditions of anticoagulant, stannous ion concentration, incubation time, and incubation temperature. This procedure was used to investigate the effects of various agents on Tc-99m RBC labeling yields. These agents were inorganic ions, therapeutic agents, biochemicals, chelating agents, oxidizing agents, an...
Resource Type:: Dissertation
Full Text:: Decay, ( % ) Y-Ray Energy, MeV Fe-52 8.2 h Positron (56) 0.165 EC (44) 0.511 Fe-59 45 d Negatron (100

Creator:: Niibori, Yoshiko
Abstract:: Long-term stimuli of many systems leads to decreased cellular responsiveness, or desensitization. We characterized the desensitization of angiotensin II (Ang 11)-mediated inositol phospholipid (IP) hydrolysis in cultured human aortic smooth muscle cells (HASMC). Although it has been suggested that the desensitization induced by long-term Mg II exposure may result partially...
Resource Type:: Masters Thesis

Creator:: Carpenter, Evan L.
Abstract:: Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Resource Type:: Dissertation

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation

Creator:: Rathore, Hargovind S.
Resource Type:: Dissertation
Full Text:: kidney Na+,e-ATPase (EC 3.6.1.3). The most potent inhibitors were the 166 - formyl derivatives 31,35,49

Creator:: Sloat, Brian R.
Abstract:: Currently, the only anthrax vaccine licensed for human use in the United States is the Anthrax-vaccine-absorbed (AVA or Biothrax®). AVA suffers from several drawbacks, including a complicated and lengthy dosing schedule that requires six initial injections administered over eighteen months, followed by annual boosters. Therefore, a new generation anthrax vaccine...
Resource Type:: Dissertation

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