Index Catalog // ScholarsArchive@OSU

Transcriptional regulation of mouse epidermal permeability barrier development and homeostasis by Ctip2

Creator:: Wang, Zhixing
Abstract:: Skin is the largest organ in the body that protects the organism from environmental, chemical and physical traumas of each passing day. The protective skin epidermal permeability barrier (EPB) is formed within the exterior layers of the epidermis, which are regularly sloughed off and repopulated by movement of inner cells....
Resource Type:: Dissertation
Full Text:: bricks and the lipids as the mortar to seal together the CEs (Elias, 1983; Nemes and Steinert, 1999

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: . Miranda, C. L., V. D. Elias, J. J. Hay, J. Choi, R. L. Reed, and J. F. Stevens. 2016. Xanthohumol

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Creator:: Li, Shan
Abstract:: Mammalian skin is the largest organ of the body and serves as a barrier to protect the body against chemical, mechanical and pathogenic insults as well as water loss. The epidermis is formed from the primitive ectoderm into a multilayered stratified epithelium, consisting of basal, spinous, granular and outermost cornified...
Resource Type:: Dissertation
Full Text:: by Dr. Arup K. Indra and Shan Li. Dr. Christane V Lohr (pathological assessments of histological

Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling

Creator:: Zhang, Ling-juan, Bhattacharya, Shreya, Leid, Mark, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Epidermal morphogenesis results from a delicate balance between keratinocyte proliferation and differentiation, and this balance is perturbed upon deletion of transcription factor Ctip2. Here we demonstrate that Ctip2, in a cell autonomous manner, controls keratinocyte proliferation and cytoskeletal organization, and regulates the onset and maintenance of differentiation in keratinocytes in...
Resource Type:: Article
Full Text:: with the emergence of a competent permeability barrier (Elias et al., 1998). Considered together

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

Creator:: Hoyt, Dale G.
Abstract:: Previous investigation showed that 20 mg/kg BCNU caused inhibition of sulfobromophthalein (BSP) excretion and inhibited bile salt independent bile flow (BSIF) in rats by 48 h after treatment (Hoyt, 1984). The present investigation demonstrated that BCNU inhibited the canalicular step in the excretion of BSP. This was indicated by the...
Resource Type:: Dissertation
Full Text:: 84 DISCUSSION 94 Chapter V. The Effect of Cholestyramine on the Impairment of Excretory Function by

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Creator:: Wang, Zhixing, Zhang, Ling-juan, Guha, Gunjan, Li, Shan, Kyrylkova, Kateryna, Kioussi, Chrissa, Leid, Mark, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Background: Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal differentiation, as well as altered lipid composition during development. However, little is known about the role of Ctip2...
Resource Type:: Article

Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

Creator:: Hoyt, Dale G.
Abstract:: BCNU caused severe cholestasis in rats after a single intraperitoneal injection. The cholestasis was characterized by a selective reduction of the bile salt independent bile flow to 11% of control. Decreased food or water consumption by the treated rats apparently did not contribute to cholestasis. Measurements of plasma Na⁺ and...
Resource Type:: Masters Thesis
Full Text:: Science Completed April 13, 1984 Commencement June 1984 APPROVED: Redacted for privacy _ v CI

Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin, Preparation of orally disintegrating tablets of melatonin and acetaminophen, Pharmacokinetics of terbinafine in penguins

Creator:: Le, Hang Thi
Abstract:: The first project of this thesis is an in vitro study. This study was performed with 8 hydrocortisone topical products on the market for the purpose of comparing one Tec Lab product, a Corticool gel, to the other seven common products on the market. The permeation of these products was...
Resource Type:: Dissertation

Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

Creator:: Al Fatease, Adel
Abstract:: Utilizing nanocarrier based drug delivery for improving the magnitude of efficacy of chemotherapeutic agents in many diseases has acquired more attention in research applications. It has shown promising results in both preclinical and clinical trials. The Food and Drug Administration (FDA) has approved many of these polymeric carriers, and tens...
Resource Type:: Dissertation
Full Text:: status and future prospects. The FASEB journal. 2005;19(3):311-30. 7. Wagner V, Dullaart A, Bock A

Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

Creator:: Sabei, Fahad Yahya
Abstract:: Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
Resource Type:: Dissertation
Full Text:: approach consists of various cycles of non-specific toxic combinations of vincristine (V), doxorubicin (D

ScholarsArchive@OSU

Transcriptional regulation of mouse epidermal permeability barrier development and homeostasis by Ctip2

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin, Preparation of orally disintegrating tablets of melatonin and acetaminophen, Pharmacokinetics of terbinafine in penguins

Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

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