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Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Creator:: Suvanakoot, Uthai
Abstract:: A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
Resource Type:: Dissertation
Full Text:: physiological availability from solid dosage forms are largely dependent upon having the drug in the dissolved

Pharmacokinetics of theophylline and it's N-7 derivatives in rabbits

Creator:: Tavipatana, Wattanaporn
Abstract:: Pharmacokinetics of theophylline and N-7 substituted theophylline in rabbits when administered alone and in various combinations were investigated. This thesis has four chapters dealing with etophylline and theophylline; proxyphylline and theophylline; dyphylline and theophylline; and etophylline, proxyphylline and dyphylline pharmacokinetics when administered concomitantly. All chapters are interrelated. Each chapter has...
Resource Type:: Masters Thesis
Full Text:: has no significant effect on the pharmacokinetic behavior of theophylline, including protein or

Purine nucleotide-induced seizures in rat prepiriform cortex

Creator:: Zhao, Xiaoqin S.
Resource Type:: Masters Thesis
Full Text:: anticonvulsant effect of 2 methylthio-ATP is therefore likely to be due to its breakdown to 2-methylthio

Adenosine receptor modulation of seizure susceptibility in rats

Creator:: Szot, Patricia
Abstract:: Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...
Resource Type:: Dissertation
Full Text:: observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA

Pharmacological characterization of the porcine atrial A₁ adenosine receptor

Creator:: Leid, Mark
Abstract:: Cardiac A₁ adenosine receptors mediate cardioinhibitory properties of adenosine and structural congeners. The objective of these studies was to increase our understanding of molecular processes involved in ligand interactions with receptors mediating cardioinhibitory effects of adenosine and the interactions of these receptors with guanine nucleotide binding regulatory proteins. Porcine atrial...
Resource Type:: Dissertation
Full Text:: I -1 Physiological effects of adenosine in various tissues and cell types 18 CHAPTER II II -1

Interactions of pyrethroid insecticides with GABAA and peripheral-type benzodiazepine receptors

Creator:: Devaud, Leslie L.
Resource Type:: Dissertation
Full Text:: ]Ro5-4864 binding to rat olfactory bulb membranes: effect of cismethrin. 16. Schild plot of

Modulation of sensory afferent processing by endogenous spinal adenosine

Creator:: Keil, Gary J.
Resource Type:: Dissertation
Full Text:: independent systems to achieve a common physiological or 10 pharmacological effect. A number of

Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

Creator:: Zhang, Ge
Abstract:: Although considerable experimental evidence suggests that endogenous adenosine may function as a modulator of neuronal activity in the etiology or control of seizures, the neuroanatomical and neurochemical basis for the anticonvulsant actions of adenosine have not been well established. A discrete brain region of possible fundamental importance to epileptogenisis within...
Resource Type:: Masters Thesis
Full Text:: rank order potency, degree of stereoselectivity for R-PIA vs S-PIA and lack of anticonvulsant effect

Activation of adenosine receptors in prepiriform cortex modulates seizure susceptibility

Creator:: Zhang, Ge, 1956-
Resource Type:: Dissertation
Full Text:: ; and the anticonvulsant effect of NECA was completely abolished by the adenosine receptor antagonist 8

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

Creator:: Taur, Jan-Shiang
Abstract:: The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhibiting metabolizing enzymes or inhibiting the drug efflux transporters. However, the effect of dietary flavonoids...
Resource Type:: Dissertation
Full Text:: inhibiting the drug efflux transporters. However, the effect of dietary flavonoids in the absorption of

ScholarsArchive@OSU

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Pharmacokinetics of theophylline and it's N-7 derivatives in rabbits

Purine nucleotide-induced seizures in rat prepiriform cortex

Adenosine receptor modulation of seizure susceptibility in rats

Pharmacological characterization of the porcine atrial A₁ adenosine receptor

Interactions of pyrethroid insecticides with GABAA and peripheral-type benzodiazepine receptors

Modulation of sensory afferent processing by endogenous spinal adenosine

Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

Activation of adenosine receptors in prepiriform cortex modulates seizure susceptibility

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

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