Index Catalog // ScholarsArchive@OSU

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation

Intraperitoneal Nanotherapy for Metastatic Ovarian Cancer Based on siRNA-Mediated Suppression of DJ-1 Protein Combined with a Low Dose of Cisplatin

Creator:: Schumann, Canan, Chan, Stephanie, Millar, Jess A., Bortnyak, Yuliya, Carey, Katherine, Fedchyk, Alex, Wong, Leon, Korzun, Tetiana, Moses, Abraham S., Lorenz, Anna, Shea, Delaney, Taratula, Olena, Khalimonchuk, Oleh, and Taratula, Oleh
Abstract:: Herein, we report an efficient combinatorial therapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin. DJ-1 protein modulates, either directly or indirectly, different oncogenic pathways that support and promote survival, growth, and invasion of ovarian cancer cells. To evaluate the...
Resource Type:: Article
Full Text:: therapeutic target. Biochem Pharmacol. 2015; 93:241–50. [PubMed: 25498803] 9. Chen Y, Kang M, Lu W, Guo Q

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Creator:: Schumann, Canan B.
Abstract:: Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
Resource Type:: Dissertation

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Creator:: Doddapaneni, Bhuvana S.
Abstract:: Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
Resource Type:: Dissertation
Full Text:: . Wang, X. Tang, J. Han, Y. Ding, W. Guo and M. Pei, Macromol Biosci, 2016, 16, 774-783. [4] D. G

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Creator:: Eida, Auday
Abstract:: Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
Resource Type:: Dissertation
Full Text:: , and abundancy of sp3 hybridized carbons and chiral centers (Guo, 2017). Being products of biological

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Creator:: Cote, Brianna M.
Abstract:: Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
Resource Type:: Dissertation

Safety of Phytoestrogenic Botanical Dietary Supplements: in vivo and in vitro Evaluation of Botanical-Drug Interactions

Creator:: Chen, Luying
Abstract:: Popular botanical dietary supplements marketed for management of menopausal symptoms, including hops (Humulus lupulus L.), red clover (Trifolium pratense) and licorice (Glycyrrhiza uralensis), were evaluated for their potential to alter CYP-mediated drug metabolism clinically and pre-clinically. Both hops and red clover had been reported to inhibit certain cytochrome P450 (CYP)...
Resource Type:: Dissertation

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Creator:: Vyshenska, Dariia
Abstract:: Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
Resource Type:: Dissertation

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Creator:: Andrianasolo, Eric Hajaniriana
Abstract:: This thesis is an investigation of the natural products deriving from marine algae and cyanobacteria and has resulted in the discovery of eleven new secondary metabolites. The structure elucidations of these new molecules were performed using a variety of spectroscopic techniques. Four new macrolides were isolated and characterized from the...
Resource Type:: Dissertation

ScholarsArchive@OSU

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Intraperitoneal Nanotherapy for Metastatic Ovarian Cancer Based on siRNA-Mediated Suppression of DJ-1 Protein Combined with a Low Dose of Cisplatin

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Safety of Phytoestrogenic Botanical Dietary Supplements: in vivo and in vitro Evaluation of Botanical-Drug Interactions

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

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