Index Catalog // ScholarsArchive@OSU

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation
Full Text:: a period of 12 hours. ©Copyright by Iman Saad Ahmed September 4, 2002 All Rights Reserved (1

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: Pharmacy presented on February 1, 2010. Title: The Study of Pharmacokinetics in a Clinical Environment

Creator:: Taratula, Oleh, Kuzmov, Andriy, Shah, Milin, Garbuzenko, Olga B., and Minko, Tamara
Abstract:: We developed, synthesized, and tested a multifunctional nanostructured lipid nanocarrier- based system (NLCS) for efficient delivery of an anticancer drug and siRNA directly into the lungs by inhalation. The system contains: (1) nanostructured lipid carriers (NLC); (2) anticancer drug (doxorubicin or paclitaxel); (3) siRNA targeted to MRP1 mRNA as a...
Resource Type:: Article
Full Text:: (2013), doi: 10.1016/j.jconrel.2013.04.018 This is a PDF file of an unedited manuscript that has been

Creator:: Suvanakoot, Uthai
Abstract:: A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
Resource Type:: Dissertation
Full Text:: Theophylline Injections in Pigs Redacted for privacy Abstract approved. `'Io'hrIMN:ChrisIteisen,-Pla. A two

Creator:: Hardardt, Elizabeth Ann
Abstract:: This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Resource Type:: Masters Thesis
Full Text:: Dr. Jan Frederik Stevens This work sought to characterize a link between Vitamin C and

Creator:: Niibori, Yoshiko
Abstract:: Long-term stimuli of many systems leads to decreased cellular responsiveness, or desensitization. We characterized the desensitization of angiotensin II (Ang 11)-mediated inositol phospholipid (IP) hydrolysis in cultured human aortic smooth muscle cells (HASMC). Although it has been suggested that the desensitization induced by long-term Mg II exposure may result partially...
Resource Type:: Masters Thesis
Full Text:: and PLC-3. Mg II pretreatment reduced IP accumulation induced by Ang II (lp.M) in a time-dependent

Creator:: Kasiwong, Srirat
Resource Type:: Dissertation
Full Text:: ampicillin trihydrate were given to llamas by intramuscular(IM) administration at a dose of 12 mg/kg. The

Creator:: Fan, Ying
Abstract:: This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
Resource Type:: Dissertation
Full Text:: products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A

ScholarsArchive@OSU