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Filtering by: Creator Kennard, Paul Academic Affiliation College of Pharmacy

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:

Han, Bingnan

Abstract:

This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...

Resource Type:

Dissertation
Natural products studies of the marine cyanobacterium Lyngbya majuscula

Creator:

Sitachitta, Namthip

Abstract:

The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide. The chemical studies with a Grenada collection...

Resource Type:

Dissertation
Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:

Marquez, Brian L.

Abstract:

This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...

Resource Type:

Dissertation

Full Text:

. Leusch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J.; Corbett, T. H. J. Am. Chem. Soc. ASAP article. 7