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Filtering by: Subject Ketoconazole -- Mechanism of action Academic Affiliation College of Pharmacy

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Creator:

Buckholz, Cheryl J.

Abstract:

Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...

Resource Type:

Dissertation

Full Text:

vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there
Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Creator:

Abuelizz, Hatem A.

Abstract:

This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...

Resource Type:

Dissertation

Full Text:

specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a