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Filtering by: Creator Kienast, Stephanie S. Academic Affiliation College of Pharmacy

Intraperitoneal Nanotherapy for Metastatic Ovarian Cancer Based on siRNA-Mediated Suppression of DJ-1 Protein Combined with a Low Dose of Cisplatin

Creator:

Schumann, Canan, Chan, Stephanie, Millar, Jess A., Bortnyak, Yuliya, Carey, Katherine, Fedchyk, Alex, Wong, Leon, Korzun, Tetiana, Moses, Abraham S., Lorenz, Anna, Shea, Delaney, Taratula, Olena, Khalimonchuk, Oleh, and Taratula, Oleh

Abstract:

Herein, we report an efficient combinatorial therapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin. DJ-1 protein modulates, either directly or indirectly, different oncogenic pathways that support and promote survival, growth, and invasion of ovarian cancer cells. To evaluate the...

Resource Type:

Article

Full Text:

Combined with a Low Dose of Cisplatin Canan Schumann, PharmDa,#, Stephanie Chana,#, Jess A. Millar, MSb