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Bioactive natural products from marine algae

Creator:: Tan, Lik Tong
Abstract:: This thesis is an account of my investigation on the natural products deriving from various marine algae and has resulted in the discovery of thirteen novel bioactive metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D...
Resource Type:: Dissertation
Full Text:: THE THESIS OF Lik Tong Tan for the degree of Doctor of Philosophy in Pharmacy presented on April 26

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: stroke (Choi et al., 1988; Lee et al., 1999). In addition, NMDA type glutamate 3 receptors has

Effect of pharmaceuticals and natural products on multidrug resistance mediatedtransport in Caco-2 and MDCKII-MDR1 drug transport models

Creator:: Fan, Ying
Abstract:: This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
Resource Type:: Dissertation

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:: Carpenter, Evan L.
Abstract:: Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Resource Type:: Dissertation

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Creator:: Albarqi, Hassan Ahmad M.
Abstract:: Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
Resource Type:: Dissertation
Full Text:: 2008, 20 (20), 204133. 30. Tong, S.; Quinto, C. A.; Zhang, L.; Mohindra, P.; Bao, G., Size

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Creator:: Zhang, Lingjuan
Abstract:: COUP-TFI, an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily, plays important roles in homeostasis and the CNS development, including differentiation, patterning, axonal projection, cell migration, cortical arealization and the temporal specification of neural stem cells. A number of COUP-interacting proteins have been described previously, and the majority of...
Resource Type:: Dissertation
Full Text:: enzyme UBC9 (Desterro et al., 1999; Johnson and Blobel, 1997; Lee et al., 1998; Saitoh et al., 1998

Multicenter Study of High-Dose Daptomycin for Treatment of Enterococcal Infections

Creator:: Casapao, Anthony M., Kullar, Ravina, Davis, Susan L., Levine, Donald P., Zhao, Jing J., Potoski, Brian A., Goff, Debra A., Crank, Christopher W., Segreti, John, Sakoulas, George, Cosgrove, Sara E., and Rybak, Michael J.
Abstract:: Enterococci are among the leading pathogens isolated in hospital-acquired infections. Current antimicrobial options for vancomycin- resistant enterococci (VRE) are limited. Prior data suggest that daptomycin at>6 mg/kg of body weight/day may be used to treat enterococcal infections. We retrospectively evaluated the effectiveness and safety of high-dose daptomycin (HD-daptomycin) therapy (>6...
Resource Type:: Article
Full Text:: YP, Lee SO, Song EH, Lee EJ, Jang EY, Kim SH, Choi SH, Kim MN, Jeong JY, Woo JH, Kim YS. 2010

Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

Creator:: Osborn, Andrew
Abstract:: Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
Resource Type:: Dissertation
Full Text:: . Dr. Kelsey Kean, Dr. Khaled Almabruk, Dr. Shumpei Asamizu, and Janet Lee characterized EEVS

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: derangements. Journal of lipid research 60: 1547-1561. 52. Huang, C., J. Wang, W. Hu, C. Wang, X. Lu, L. Tong

Transcriptional repression by CTIP2, a C2H2 zinc finger protein

Creator:: Topark-Ngarm, Acharawan Khamsiritrakul
Abstract:: CTIP2, a novel C2H2 zinc finger protein, is a transcriptional repressor that functions by at least two mechanisms. CTIP2 interacts with and stimulates transcriptional repression mediated by COUP-TF family members. CTIP2 also represses transcription independently of COUP-TF proteins by direct, sequence-specific DNA binding activity. CTIP2 has been implicated in lymphoid...
Resource Type:: Dissertation
Full Text:: Venkataraman, Gaurav Bajaj, and Yi-chen Lee. I also thank former members of the Leid and Ishmael Laboratories

ScholarsArchive@OSU

Bioactive natural products from marine algae

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Effect of pharmaceuticals and natural products on multidrug resistance mediatedtransport in Caco-2 and MDCKII-MDR1 drug transport models

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Multicenter Study of High-Dose Daptomycin for Treatment of Enterococcal Infections

Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Transcriptional repression by CTIP2, a C2H2 zinc finger protein

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