Index Catalog // ScholarsArchive@OSU

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Creator:: Lee, Beom-jin
Resource Type:: Dissertation
Full Text:: -Jin Lee for the degree of Doctor of Philosophy in Pharmacy (Pharmaceutics) presented on December 8

Development of a transdermal delivery system for melatonin

Creator:: Lee, Ya-ling
Abstract:: Melatonin is an neurohormone secreted by the pineal gland. Several therapeutic possibilities for melatonin administration have been suggested. However, clinical studies with melatonin have been limited by lack of a delivery system capable of mimicking the physiological release pattern of melatonin. There is an increasing recognition that the skin can...
Resource Type:: Masters Thesis
Full Text:: melatonin AN ABSTRACT OF THE THESIS OF Ya-Ling Lee for the degree of Master of Science in Pharmacy

Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Creator:: Nguyen, Duc X.
Abstract:: TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...
Resource Type:: Dissertation
Full Text:: , Dr. David Lee, and Dr. Natalia Shulzhenko for providing me with valuable insights and for guiding

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Creator:: Back, Daniel C.
Abstract:: Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
Resource Type:: Dissertation
Full Text:: of getting to know. I especially thank Xinhui Yu, Dr. Richard Tehan, Dr. George Neuhaus, and Dr

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Creator:: Cavalier, Michael C., Yim, Young-Sun, Asamizu, Shumpei, Neau, David, Almabruk, Khaled H., Mahmud, Taifo, and Lee, Yong-Hwan
Abstract:: The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of...
Resource Type:: Article
Full Text:: , Minagawa K, Yu Y, et al. (2006) Functional analysis of the validamycin biosynthetic gene cluster and

Potential Therapeutic Competition in Community-Living Older Adults in the U.S.: Use of Medications That May Adversely Affect a Coexisting Condition

Creator:: Lorgunpai, Songprod Jonathan, Grammas, Marianthe, Lee, David S. H., McAvay, Gail, Charpentier, Peter, and Tinetti, Mary E.
Abstract:: OBJECTIVE: The 75% of older adults with multiple chronic conditions are at risk of therapeutic competition (i.e. treatment for one condition may adversely affect a coexisting condition). The objective was to determine the prevalence of potential therapeutic competition in community-living older adults. METHODS: Cross-sectional descriptive study of a representative sample...
Resource Type:: Article
Full Text:: Affect a Coexisting Condition Lorgunpai SJ, Grammas M, Lee DSH, McAvay G, Charpentier P, et al. (2014

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation

Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells

Creator:: Taratula, Olena, Dani, Raj Kumar, Schumann, Canan, Xu, Hong, Wang, Andrew, Song, Han, Dhagat, Pallavi, and Taratula, Oleh
Abstract:: A multifunctional tumor-targeting delivery system was developed and evaluated for an efficient treatment of drug-resistant ovarian cancer by combinatorial therapeutic modality based on chemotherapy and mild hyperthermia. The engineered iron oxide nanoparticle (IONPs)-based nanocarrier served as an efficient delivery vehicle for doxorubicin and provided the ability to heat cancer cells...
Resource Type:: Article
Full Text:: cancer tumors (Lee et al., 2011; Pradhan et al., 2010). Moreover, there is an 80 opportunity to modify

Formulation and pharmacokinetics of melatonin

Creator:: Konsil, Julraht
Resource Type:: Dissertation

Regulation of inositol phospholipid hydrolysis by extended treatment with angiotensin II in human aortic smooth muscle cells

Creator:: Niibori, Yoshiko
Abstract:: Long-term stimuli of many systems leads to decreased cellular responsiveness, or desensitization. We characterized the desensitization of angiotensin II (Ang 11)-mediated inositol phospholipid (IP) hydrolysis in cultured human aortic smooth muscle cells (HASMC). Although it has been suggested that the desensitization induced by long-term Mg II exposure may result partially...
Resource Type:: Masters Thesis
Full Text:: Sternweis, 1993; Lee et al., 1994; Park et al., 1993), may also be phosphorylated (Wieland et al., 1993

ScholarsArchive@OSU

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Development of a transdermal delivery system for melatonin

Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Potential Therapeutic Competition in Community-Living Older Adults in the U.S.: Use of Medications That May Adversely Affect a Coexisting Condition

New product formulation and multiple dose pharmacokinetics of acetaminophen

Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells

Formulation and pharmacokinetics of melatonin

Regulation of inositol phospholipid hydrolysis by extended treatment with angiotensin II in human aortic smooth muscle cells

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