Index Catalog // ScholarsArchive@OSU

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Creator:: Lande, Claire, Rao, Sujaya, Morre, Jeffrey T., Galindo, Gracie, Kirby, Julie, Reardon, Patrick N., Bobe, Gerd, and Stevens, Jan Frederik
Abstract:: Linden (Tilia spp.), a profusely flowering temperate tree that provides bees with vital pollen and nectar, has been associated with bumble bee (Bombus spp.) mortality in Europe and North America. Bee deaths have been attributed, with inadequate evidence, to toxicity from mannose in nectar or starvation due to low nectar...
Resource Type:: Article
Full Text:: security, and environmental health. Worldwide, there have been reports of declines in bee populations due

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: and Environmental Mutagenesis 632: 1-8. 18 31. Gerhäuser, C. 2005. Broad spectrum

Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

Creator:: Nosal, Daniel Grzegorz
Abstract:: Superwarfarins are anticoagulant rodenticides that are 100 times more potent and 15 times more persistent than warfarin. They have been used since the 1980s and cause over 10,000 cases of accidental and intentional poisonings per year. Apart from inducing uncontrollable bleeding, by inhibiting the vitamin K cycle, superwarfarins can disrupt...
Resource Type:: Dissertation
Full Text:: ,† Douglas L. Feinstein,‡ Luying Chen,† and Richard B. van Breemen† † Linus Pauling Institute

Nonmuscle myosins II-B and Va are components of detergentresistant membrane skeletons derived from mouse forebrain

Creator:: Ishmael, Jane E., Safic, Masa, Amparan, David, Vogel, Walter K., Pham, Tuyen, Marley, Kevin, Filtz, Theresa M., and Maier, Claudia S.
Abstract:: Myosins are actin-based molecular motors that may have specialized trafficking and contractile functions in cytoskeletal compartments that lack microtubules. The postsynaptic excitatory synapse is one such specialization, yet little is known about the spatial organization of myosin motor proteins in the mature brain. We used a proteomics approach to determine...
Resource Type:: Preprint and Article
Full Text:: 2, and the Environmental Health Sciences Center 3, Oregon State University, Corvallis, Oregon

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation
Full Text:: , data collection and writing of Chapter 3. Dr. Rosita R. Proteau, Dr. Jan F. Stevens (Linus Pauling

Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

Creator:: Newman, Nolan K.
Abstract:: The gut microbiome has been previously implemented in a number of diseases. Of note is its substantial role in metabolic syndrome, which encapsulates a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and stroke. Understanding the causal relationships between the gut microbiome and host processes...
Resource Type:: Dissertation
Full Text:: environmental conditions may result in an overabundance of harmful microbes and/or the decrease of beneficial

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation
Full Text:: controversial role in the late career of Linus Pauling in the fight against cancer and the common cold, the

Safety of Phytoestrogenic Botanical Dietary Supplements: in vivo and in vitro Evaluation of Botanical-Drug Interactions

Creator:: Chen, Luying
Abstract:: Popular botanical dietary supplements marketed for management of menopausal symptoms, including hops (Humulus lupulus L.), red clover (Trifolium pratense) and licorice (Glycyrrhiza uralensis), were evaluated for their potential to alter CYP-mediated drug metabolism clinically and pre-clinically. Both hops and red clover had been reported to inhibit certain cytochrome P450 (CYP)...
Resource Type:: Dissertation
Full Text:: . Jaewoo Choi and Scott Leonard from Linus Pauling Institute, Oregon State University. The projects

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:: Hardardt, Elizabeth Ann
Abstract:: This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Resource Type:: Masters Thesis
Full Text:: Jeff Morré, the Linus Pauling Institute, the College of Pharmacy, especially Drs. Gary DeLander and

Effects of Medicinal Herbs on Contraction Rate of Cultured Cardiomyocyte. Possible Mechanisms Involved in the Chronotropic Effects of Hawthorn and Berberine in Neonatal Murine Cardiomyocyte

Creator:: Salehi, Satin
Abstract:: Herbs have been used for many centuries in diverse civilizations for the treatment of heart disease. Only a few natural supplements claim to have direct cardiovascular actions including hawthorn (Crataegus spp.) and berberine derived from the Berberidaceae family. Several different studies indicate important cardiovascular effects of hawthorn and berberine. For...
Resource Type:: Dissertation
Full Text:: appreciation to Debra Peters for her support. I acknowledge the support of the Linus Pauling Institute

ScholarsArchive@OSU

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

Nonmuscle myosins II-B and Va are components of detergentresistant membrane skeletons derived from mouse forebrain

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Safety of Phytoestrogenic Botanical Dietary Supplements: in vivo and in vitro Evaluation of Botanical-Drug Interactions

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Effects of Medicinal Herbs on Contraction Rate of Cultured Cardiomyocyte. Possible Mechanisms Involved in the Chronotropic Effects of Hawthorn and Berberine in Neonatal Murine Cardiomyocyte

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