Index Catalog // ScholarsArchive@OSU

Development of Hot-melt Pan-coating, Application to Sustained-release Capsules and Tamper Resistant-coating. 2) Formulation of Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules. 3) Novel Sustained Release Tablet of Glipizide: Compression of Coated Drug Beads, Formulation, Dissolution, and Convolution. 4) Verapamil Sustained Release: New Formulation and Convolution

Creator:: Nguyen, Chien Ngoc
Abstract:: Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Chien Ngoc Nguyen for the degree of Doctor of Philosophy in Pharmacy presented on November

Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Creator:: Nguyen, Duc X.
Abstract:: TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...
Resource Type:: Dissertation
Full Text:: Nguyen for the degree of Doctor of Philosophy in Pharmaceutical Sciences presented on March 14, 2018

Partial purification and characterization of L-pipecolic acid dehydrogenase from rabbit kidney cortex

Creator:: DeHart, Jennifer E.
Resource Type:: Masters Thesis
Full Text:: , Prof. T. Mark Zabriskie. Mark allowed me to venture in my own direction, even when it was an obvious

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: from Symbiotic Marine Organisms II. Enzvmologv of Blasticidin S Biosynthesis. Abstract approved: T

Comparison and optimization of chromatographic conditions for separation of cyclic dynorphin A analogues from linear byproducts

Creator:: Leelasvatanakij, Leena
Resource Type:: Masters Thesis
Full Text:: . Thirdly, I would like to acknowledge my committee members, Dr. Michael W. Schuyler, Dr. T. Mark Zabriskie

Roles of homeodomain transcription factors during organogenesis

Creator:: Xu, Jun
Abstract:: The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
Resource Type:: Dissertation
Full Text:: potential neuronal function in neural tube. The T box, Hox gene families and Pax genes were identified as

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Creator:: Nogle, Lisa Marie
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
Resource Type:: Dissertation
Full Text:: the new ct-pyrone malyngamide T. A collection of L. majuscula from Antany Mora, Madagascar, led to

The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

Creator:: Kyrylkova, Kateryna
Abstract:: BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
Resource Type:: Dissertation
Full Text:: ., Della Valle, V., Monni, R., Nguyen Khac, F., Mercher, T., Penard-Lacronique, V., Pasturaud, P. et al

Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

Creator:: Al Fatease, Adel
Abstract:: Utilizing nanocarrier based drug delivery for improving the magnitude of efficacy of chemotherapeutic agents in many diseases has acquired more attention in research applications. It has shown promising results in both preclinical and clinical trials. The Food and Drug Administration (FDA) has approved many of these polymeric carriers, and tens...
Resource Type:: Dissertation
Full Text:: ANGIOGENESIS ……………………………………………………………………….75 2.9 FLOW CYTOMETRIC ANALYSIS OF FOXP-3 T-REGULATORY CELLS IN

1) Preparation of Acetaminophen Capsules Containing Beads Prepared by Hot-melt Direct Blend Coating Method 2) Pharmacokinetic Modeling and Monte Carlo Simulations in The Context of Additional Criteria for Bioequivalence Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to Tendinopathy

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation
Full Text:: scientific expertise with enthusiasm. 9 This thesis is dedicated to my dear husband, Ly Nguyen, and

ScholarsArchive@OSU

Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

Partial purification and characterization of L-pipecolic acid dehydrogenase from rabbit kidney cortex

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Comparison and optimization of chromatographic conditions for separation of cyclic dynorphin A analogues from linear byproducts

Roles of homeodomain transcription factors during organogenesis

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

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