Index Catalog // ScholarsArchive@OSU

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:: Kesinger, Nicholas G.
Abstract:: Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Resource Type:: Dissertation
Full Text:: advisor- Prof. Fred Stevens. TABLE OF CONTENTS

Correlation of fecal ergovaline, lolitrem B, and their metabolites in steers fed endophyte infected perennial ryegrass straw

Creator:: Murty, Lia D.
Abstract:: Perennial ryegrass (PRG, Lolium perenne) is a hardy cool-season grass that is infected with the endophytic fungus Neotyphodium lolii, which enables the plant to be insect repellant and drought resistant, lowering the use of insecticides and fertilizers. However, this fungus produces the compound lolitrem B (LB, m/z 686.4) which causes...
Resource Type:: Masters Thesis
Full Text:: sincere appreciation to Dr. A. Morrie Craig and Dr. Fred Stevens for serving as my academic advisors and

Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites

Creator:: Knight, Eva W.
Abstract:: Myxobacteria represent an interesting class of Gram-negative soil bacteria. These bacteria utilize organic materials from the environment as a food source by the action of their extracellular hydrolytic enzymes. They grow vegetatively in the presence of adequate nutrients. During starvation conditions, however, they aggregate and form multicellular structures called fruiting...
Resource Type:: Masters Thesis

Development and broad application of a mass spectrometry based metabolomics platform

Creator:: Kirkwood, Jay Steven
Abstract:: Metabolomics is a comprehensive analysis of small molecules, or metabolites, in a system. Metabolomics is a hypothesis-generating experiment and offers an unbiased analysis of cell metabolism that can aid in the understanding of fundamental biological processes. Metabolomics is widely and broadly applicable in the biological sciences and has been used...
Resource Type:: Dissertation
Full Text:: . . Jay Steven Kirkwood, Author ACKNOWLEDGEMENTS First I thank my advisor, Fred Stevens for his

Development of xanthohumol derivatives as mild mitochondrial uncouplers for treatment of metabolic syndrome

Creator:: De Montgolfier, Oriane
Resource Type:: Masters Thesis
Full Text:: patient with all my questions: Fred Stevens, Jaewoo Choi, Val Miranda, Gerd Bobe, Yu Zhen, Ralph Reed

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:: Hardardt, Elizabeth Ann
Abstract:: This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Resource Type:: Masters Thesis
Full Text:: her mentor, Dr. Jan Fred Stevens, all the members of the Stevens Lab, especially Drs. Cristobal

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: reader upon request. Ines Leila Paraiso, Author ACKNOWLEDGEMENTS I thank Fred Stevens

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Creator:: Abuelizz, Hatem A.
Abstract:: This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
Resource Type:: Dissertation
Full Text:: work. I also thank my thesis committee members Dr. Mark Zabriskie, Dr. Kerry McPhail, Dr. Fred

Programming of Furosemide Pharmacokinetics by Intrauterine Growth Restriction and High Fat Diet in the Adult Rat

Creator:: DuBois, Barent Nathan
Abstract:: Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. I hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Pregnant...
Resource Type:: Dissertation

Application of modern NMR techniques to structure elucidation of bioactive natural products from tunicates

Creator:: Sikorska, Justyna
Abstract:: Recent developments in NMR hardware have extended the reach of natural products chemists to structure elucidation of compounds isolated on a nanomolar scale. In parallel with advances in hardware new NMR techniques for structure elucidation have evolved, e.g. quantitative NOEs, residual dipolar couplings (RDCs)and diffusion-ordered spectroscopy (DOSY). The application of...
Resource Type:: Dissertation

ScholarsArchive@OSU

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Correlation of fecal ergovaline, lolitrem B, and their metabolites in steers fed endophyte infected perennial ryegrass straw

Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites

Development and broad application of a mass spectrometry based metabolomics platform

Development of xanthohumol derivatives as mild mitochondrial uncouplers for treatment of metabolic syndrome

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Programming of Furosemide Pharmacokinetics by Intrauterine Growth Restriction and High Fat Diet in the Adult Rat

Application of modern NMR techniques to structure elucidation of bioactive natural products from tunicates

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