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Filtering by: Funding statement Supported in part by NIH award R01GM96685 through the NSF/NIH Ecology and Evolution of Infectious Disease Program. Remove constraint Funding statement: Supported in part by NIH award R01GM96685 through the NSF/NIH Ecology and Evolution of Infectious Disease Program. Academic Affiliation College of Pharmacy Remove constraint Academic Affiliation: College of Pharmacy

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  • Studies on the ecological functions of the antidiabetic drugs acarbose

    Creator:
    Tanoeyadi, Samuel
    Abstract:
    Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature. Many secondary metabolites isolated from plants and microbes have found use as molecular probes, drug leads, or medicine...
    Resource Type:
    Masters Thesis
    Full Text:
    presence of a natural product. The first two mechanisms have been studied in great depth and adapted by

  • Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

    Creator:
    Vining, Oliver B.
    Abstract:
    Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
    Resource Type:
    Dissertation
    Full Text:
    development of natural products into new therapeutics has dwindled, in part due to the challenges posed by

  • Marine algal secondary metabolites of unique structure and biomedicinal or agrichemical potential

    Creator:
    Milligan, Kenneth Edward
    Abstract:
    This thesis describes investigations of marine algal secondary metabolites, with particular interest in their biomedical and agrichemical potential. Invaluable in such pursuits have been the access and application of advanced spectroscopic techniques, such as NMR, and the ability to assess the biological activity of the algal samples in a variety...
    Resource Type:
    Dissertation
    Full Text:
    Biodiversity Group (ICBG) initiated by the NCI and NIH to explore the uses of natural products in the

  • Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

    Creator:
    Blanchard, David, L.
    Abstract:
    L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
    Resource Type:
    Dissertation
    Full Text:
    result in hospitalization or death,9 and the number of new epilepsy cases increases by 200,000 each

  • Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

    Creator:
    Wierzbicki, Igor H.
    Abstract:
    The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
    Resource Type:
    Dissertation
    Full Text:
    The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human

  • Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

    Creator:
    Wan, Xuemei
    Abstract:
    Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...
    Resource Type:
    Dissertation
    Full Text:
    benifits and remain part of standard-of-care in the treatment of many solid tumors. Moreover, although

  • Investigation of unique marine environments for microbial natural products

    Creator:
    Thornburg, Christopher C.
    Abstract:
    Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
    Resource Type:
    Dissertation
    Full Text:
    by the U.S. Food and Drug Administration (FDA), European Commission (EC) or in various stages of

  • Regulation of Secondary Metabolite Production in Streptomyces

    Creator:
    Abdullah, Alanzi R.
    Abstract:
    Among the myriad of natural products are pseudosugar-containing secondary metabolites, e.g., the C7-pseudosugar-containing oligosaccharide acarbose, the C6- pseudosugar-containing aminoglycoside antibiotics, and the five-membered ring pseudosugar-containing antibiotic pactamycin. The C7-pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called sedoheptulose 7-phosphate cyclases (SH7PCs). This family of enzymes...
    Resource Type:
    Dissertation
    Full Text:
    bacterial kingdom, the products of the BGCs and their functions in nature are largely unknown. As part of

  • Novel oxylipins and other bioactive metabolites from marine algae

    Creator:
    Nagle, Dale George
    Abstract:
    I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
    Resource Type:
    Dissertation
    Full Text:
    assays used to guide the fractionation and purification of curacin A were performed, in this case, by