Index Catalog // ScholarsArchive@OSU

Creator:: Selman, Wisam H.
Abstract:: Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...
Resource Type:: Dissertation
Full Text:: her efforts. I would like to acknowledge my graduate committee members. I am grateful to Dr. Mark

Creator:: Burroughs, A. Maxwell, Hoppe, Robert W., Goebel, Neal C., Sayyed, Bilal H., Voegtline, Tyler J., Schwabacher, Alan W., Zabriskie, T. Mark, and Silvaggi, Nicholas R.
Abstract:: The nonproteinogenic amino acid enduracididine is a critical component of the mannopeptimycins, cyclic glycopeptide antibiotics with activity against drug-resistant pathogens, including methicillin-resistant Staphylococcus aureus. Enduracididine is produced in Streptomyces hygroscopicus by three enzymes, MppP, MppQ, and MppR. On the basis of primary sequence analysis, MppP and MppQ are pyridoxal 5'-phosphate-dependent...
Resource Type:: Article
Full Text:: . Goebel,§ Bilal H. Sayyed,‡ Tyler J. Voegtline,‡ Alan W. Schwabacher,‡ T. Mark Zabriskie,§ and Nicholas R

Creator:: Cavalier, Michael C., Yim, Young-Sun, Asamizu, Shumpei, Neau, David, Almabruk, Khaled H., Mahmud, Taifo, and Lee, Yong-Hwan
Abstract:: The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of...
Resource Type:: Article
Full Text:: . Residues/molecules of interest are represented in stick models. The dotted lines mark hydrogen bonds and

Creator:: Osborn, Andrew
Abstract:: Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
Resource Type:: Dissertation
Full Text:: thank my committee members, Dr. Mark Zabriskie, Dr. Philip Proteau, Dr. Daniel Rockey, and Dr. Jane

ScholarsArchive@OSU