Index Catalog // ScholarsArchive@OSU

Partial purification and characterization of L-pipecolic acid dehydrogenase from rabbit kidney cortex

Creator:: DeHart, Jennifer E.
Resource Type:: Masters Thesis
Full Text:: washes. Native gel activity stain. This procedure was adapted from Witwer and Wagner.6° L-PADH was

Investigation of unique marine environments for microbial natural products

Creator:: Thornburg, Christopher C.
Abstract:: Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
Resource Type:: Dissertation
Full Text:: Microbial Natural Products Abstract approved: Kerry L. McPhail Metagenomics has revealed that the

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:: Blanchard, David, L.
Abstract:: L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
Resource Type:: Dissertation
Full Text:: OF David L. Blanchard for the degree of Doctor of Philosophy in Pharmacy presented on March

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: General Introduction Ines L. Paraiso 3 General introduction Obesity, a public health

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Creator:: Marquez, Brian L.
Abstract:: This thesis is an account of my explorations into the field of natural products chemistry. These investigations led to the discovery of several novel secondary metabolites isolated from the marine cyanobacterium Lyngbya majuscula. In addition, biosynthetic investigations were undertaken using stable isotope-labeled precursors. The dominant role that NMR spectroscopy plays...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Brian L. Marguez for the degree of

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Laura L. Grochowski for the

The effect of cold-stress on alpha₂ modulation of transmitter release and transmitter uptake in the rat caudal artery

Creator:: Rawson, Cathleen L.
Abstract:: The level of postganglionic sympathetic nerve activity is important in determining the tone of vascular smooth muscle, and subsequent maintenance of normal blood pressure. It is generally agreed that receptors located on postganglionic nerve terminals (pre-junctional alpha₂ receptors) are important in the modulation of neurotransmitter (norepinephrine) release from these nerves....
Resource Type:: Masters Thesis
Full Text:: transmitter release and transmitter uptake in the rat caudal artery AN ABSTRACT OF THE THESIS OF Cathleen L

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Creator:: Wierzbicki, Igor H.
Abstract:: The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Resource Type:: Dissertation
Full Text:: three molecules of L-glycero-D-manno-heptoses (L,D-heptose) (Raetz and Whitfield, 2002). Heptose

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation
Full Text:: concentration (Cmax) and area under the curve (AUC0-∞) of total XN (free and conjugated) were 2.9 ± 0.1 mg/L

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

Creator:: Nogle, Lisa Marie
Abstract:: This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
Resource Type:: Dissertation
Full Text:: neuroblastoma cell line. The organic extract from a Puerto Rican L. majuscula proved remarkably rich in

ScholarsArchive@OSU

Partial purification and characterization of L-pipecolic acid dehydrogenase from rabbit kidney cortex

Investigation of unique marine environments for microbial natural products

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Structure and biosynthesis of marine cyanobacterial natural products : development and application of new NMR methods

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

The effect of cold-stress on alpha₂ modulation of transmitter release and transmitter uptake in the rat caudal artery

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

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