Index Catalog // ScholarsArchive@OSU

Purine nucleotide-induced seizures in rat prepiriform cortex

Creator:: Zhao, Xiaoqin S.
Resource Type:: Masters Thesis
Full Text:: team. I am deeply grateful to my parents, Wen-ji Lin and Shi-jian Zhao, for their love

Synthetic strategies for the preparation of affinity label dynorphin A(1-11)NH₂ analogues

Creator:: Leelasvatanakij, Leena
Resource Type:: Dissertation
Full Text:: additives) [Lancaster et al., 1991; Wu et al., 1986]. In aqueous solution, Dyn A(1-13) adopted random coil

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation

Studies on isoprenoid biosynthesis in Euglena gracilis

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: .; Wu, Y.; Wu, Y.-L.; Li, Y.; Shan, F. Synthesis, iron(lI)-induced cleavage and in vivo antimalarial

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Creator:: Abuelizz, Hatem A.
Abstract:: This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
Resource Type:: Dissertation

Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

Creator:: Osborn, Andrew
Abstract:: Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
Resource Type:: Dissertation

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Creator:: Cote, Brianna M.
Abstract:: Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
Resource Type:: Dissertation

Regulation of Secondary Metabolite Production in Streptomyces

Creator:: Abdullah, Alanzi R.
Abstract:: Among the myriad of natural products are pseudosugar-containing secondary metabolites, e.g., the C7-pseudosugar-containing oligosaccharide acarbose, the C6- pseudosugar-containing aminoglycoside antibiotics, and the five-membered ring pseudosugar-containing antibiotic pactamycin. The C7-pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called sedoheptulose 7-phosphate cyclases (SH7PCs). This family of enzymes...
Resource Type:: Dissertation

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Creator:: Kim, Jeonghwan
Abstract:: Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
Resource Type:: Dissertation

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:: Carpenter, Evan L.
Abstract:: Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Resource Type:: Dissertation

ScholarsArchive@OSU

Purine nucleotide-induced seizures in rat prepiriform cortex

Synthetic strategies for the preparation of affinity label dynorphin A(1-11)NH₂ analogues

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Studies on isoprenoid biosynthesis in Euglena gracilis

Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Regulation of Secondary Metabolite Production in Streptomyces

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

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